Congrats to Mai Luo for starting his position as an Assistant Professor at China Agricultural University
Mai Luo, a former postdoc in our lab that worked on developing new E3 ligase recruiters for targeted protein degradation applications, is starting his new…
Congrats to Mai Luo and Jessica Spradlin for their Cell Chemical Biology paper on a fully synthetic RNF114 ligand for targeted protein degradation applications!
In this paper, we describe the discovery of a fully synthetic covalent ligand EN219 that mimics the action of the more complex natural product nimbolide…
Congrats to Jessica Spradlin for graduating with her PhD from our lab and the chemistry/chemical biology program!
Congrats to Jessica Spradlin for graduating with her PhD in chemical biology! She was instrumental to our lab's work on expanding the arsenal of E3…
Our work on SARS-CoV-2 and our recent MYC inhibitor story highlighted by Mark Foundation for Cancer Research
Happy to showcase our new paper with the Maimone lab and Novartis on Keap1/Nrf2 activator Bardoxolone as a new E3 ligase recruiter for targeted protein degradation applications now out in Scientific Reports! Congrats to grad student Bingqi Tong and postdoc Mai Luo!!
Congrats to chemical biology student Lydia Boike on her paper published in Cell Chemical Biology on a covalent ligand functionally inhibiting MYC by targeting an intrinsically disordered region!!
Congrats to recent MCB-chemical biology Ph.D. graduate Carl Ward for being co-awarded the Nicholas Cozzarelli Prize!!
The Nicholas Cozzarelli Prize is awarded to MCB PhD graduates for their exceptional graduate dissertation research.
Congrats to chemical biology graduate student Jessica Spradlin for being awarded the NCI F99/K00 Predoctoral to Postdoctoral Transition Award!!
Jessica was previously an NCI F31 predoctoral fellowship recipient. The NCI Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding Ph.D. and other Research Doctoral candidates complete…
Our new discovery by postdoc Mai Luo and grad student Jessica Spradlin on a fully synthetic covalent E3 ligase RNF114 recruiter for targeted protein degradation applications on BioRxiv!
You can read the paper here at: https://www.biorxiv.org/content/10.1101/2020.07.12.198150v1
Our paper by co-first author graduate students Bingqi Tong and Jessica Spradlin in collaboration with the Maimone lab on a nimbolide-based kinase degrader that preferentially degrades oncogenic BCR-ABL over c-ABL in ACS Chemical Biology!!
You can read the paper here: https://pubs.acs.org/doi/10.1021/acschembio.0c00348#.XvIP36QXlro.twitter
Our newest work by postdoc Yosuke Isobe in collaboration with the Maimone lab on a multi-covalent natural product “superglue” asukamycin that glues together UBR7 and TP53 to activate p53 and impair cancer cell proliferation!
You can read the paper here: https://www.nature.com/articles/s41589-020-0557-2