News
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Happy to showcase our new paper with the Maimone lab and Novartis on Keap1/Nrf2 activator Bardoxolone as a new E3 ligase recruiter for targeted protein degradation applications now out in Scientific Reports! Congrats to grad student Bingqi Tong and postdoc Mai Luo!!
https://www.nature.com/articles/s41598-020-72491-9
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Congrats to chemical biology student Lydia Boike on her paper published in Cell Chemical Biology on a covalent ligand functionally inhibiting MYC by targeting an intrinsically disordered region!!
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30342-1
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Congrats to recent MCB-chemical biology Ph.D. graduate Carl Ward for being co-awarded the Nicholas Cozzarelli Prize!!
The Nicholas Cozzarelli Prize is awarded to MCB PhD graduates for their exceptional graduate dissertation research.
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Congrats to chemical biology graduate student Jessica Spradlin for being awarded the NCI F99/K00 Predoctoral to Postdoctoral Transition Award!!
Jessica was previously an NCI F31 predoctoral fellowship recipient. The NCI Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding Ph.D. and other Research Doctoral candidates complete…
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Our new discovery by postdoc Mai Luo and grad student Jessica Spradlin on a fully synthetic covalent E3 ligase RNF114 recruiter for targeted protein degradation applications on BioRxiv!
You can read the paper here at: https://www.biorxiv.org/content/10.1101/2020.07.12.198150v1
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Our paper by co-first author graduate students Bingqi Tong and Jessica Spradlin in collaboration with the Maimone lab on a nimbolide-based kinase degrader that preferentially degrades oncogenic BCR-ABL over c-ABL in ACS Chemical Biology!!
You can read the paper here: https://pubs.acs.org/doi/10.1021/acschembio.0c00348#.XvIP36QXlro.twitter
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Our newest work by postdoc Yosuke Isobe in collaboration with the Maimone lab on a multi-covalent natural product “superglue” asukamycin that glues together UBR7 and TP53 to activate p53 and impair cancer cell proliferation!
You can read the paper here: https://www.nature.com/articles/s41589-020-0557-2
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Congrats to chemical biology graduate student Lydia Boike for getting the NSF graduate fellowship and for passing her qualifying exam!!
Lydia is a second year graduate student in Chemistry/Chemical Biology and has been working on drugging undruggable transcription factors that drive cancer.