News
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Our paper on DUBTACs for targeted protein stabilization is now out!!
Congrats to co-first authors Nate Henning and Lydia Boike! https://www.nature.com/articles/s41589-022-00971-2.pdf
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Excited to present our newest discovery on the Deubiquitinase Targeting Chimera Platform for Targeted Protein Stabilization
Excited to share the newest discovery and BioRxiv preprint from our Novartis-Berkeley Center for Proteomics and Chemistry Technologies on the development of a new induced…
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Congrats to chemical biology graduate student Nate Henning for passing his qualifying exam!
Congrats to chemical biology graduate student Nate Henning for passing his qualifying exam!!
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Congrats to chemical biology graduate student Bridge Belcher for passing her qualifying exam!
Congrats to chemical biology graduate student Bridge Belcher for passing her qualifying exam!
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Congrats to Mai Luo for starting his position as an Assistant Professor at China Agricultural University
Mai Luo, a former postdoc in our lab that worked on developing new E3 ligase recruiters for targeted protein degradation applications, is starting his new…
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Congrats to Mai Luo and Jessica Spradlin for their Cell Chemical Biology paper on a fully synthetic RNF114 ligand for targeted protein degradation applications!
In this paper, we describe the discovery of a fully synthetic covalent ligand EN219 that mimics the action of the more complex natural product nimbolide…
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Congrats to Jessica Spradlin for graduating with her PhD from our lab and the chemistry/chemical biology program!
Congrats to Jessica Spradlin for graduating with her PhD in chemical biology! She was instrumental to our lab's work on expanding the arsenal of E3…
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Our work on SARS-CoV-2 and our recent MYC inhibitor story highlighted by Mark Foundation for Cancer Research
https://themarkfoundation.org/blog/an-expert-on-undruggable-targets-tackles-the-coronavirus/
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Happy to showcase our new paper with the Maimone lab and Novartis on Keap1/Nrf2 activator Bardoxolone as a new E3 ligase recruiter for targeted protein degradation applications now out in Scientific Reports! Congrats to grad student Bingqi Tong and postdoc Mai Luo!!
https://www.nature.com/articles/s41598-020-72491-9
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Congrats to chemical biology student Lydia Boike on her paper published in Cell Chemical Biology on a covalent ligand functionally inhibiting MYC by targeting an intrinsically disordered region!!
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30342-1