Our Publications


Isobe Y, Okumura M, White R, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ*, Nomura DK* (2019) Manumycin polyketides act as molecular glues between UBR7 and P53 to impair breast cancer pathogenicity. bioRxiv preprint doi:10.1101/814285. (*co-corresponding author) PDF



125. Chung CY-S*, Shin HR*, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R#, Nomura DK# (2019) Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nature Chemical Biology 15, 776-785. PMID 31285595 (*co-first authorship; #co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) PDF

124. Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK* (2019) Harnessing the anti-cancer natural product nimbolide for targeted protein degradation. Nature Chemical Biology 15, 747-755. PMID 31209351 (*co-corresponding authors) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) PDF

123. Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK (2019) Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications. ACS Chemical Biology doi: 10.1021/acschembio.8b01083. PMID 31059647 (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) PDF

122. Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD (2019) A metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity to the statin class of host-targeted therapeutics. In Press at mSphere.

121. Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature https://doi.org/10.1038/s41586-019-1705-2. PDF

120. Lim C-Y, Davis O, Shin H, Zhang J, Berdan CB, Jiang X, Counihan JL, Ory D, Nomura DK, Zoncu R (2019) ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C. Nature Cell Biology https://doi.org/10.1038/s41556-019-0391-5. PDF

119. Berdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ*, Nomura DK* (2019) Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells. Cell Chemical Biology 26, 1027-1035. PMID 31080076 (*co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) PDF

118. Lee K, Yesilkanal AE, Wynne JP, Frakenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR (2019) Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature 568, 254-258. PMID 30842661 PDF

117. Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomer MK, Parpargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA. (2019) Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Science Translational Medicine doi: 10.1126/scitranslmed.aau5758. PMID 3078288 PDF

116. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA (2019) Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nature Communications, 10, 163. PMID 30635563 PDF

115. Magtanong L, Ko P-J, To M, Cao JY, Tarangelo AN, Ward CC, Cho KY, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ (2019) Exogenous monounsaturated fatty acids suppress non-apoptotic cell death. Cell Chemical Biology doi: 10.1016/j.chembiol.2018.11.016. PMID 30686757 PDF

114. Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S (2018) Development of alky glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-to-mesechymal transition in cancer cells. European Journal of Medicinal Chemistry 163, 722-735. PMID 30576903 PDF


113. Volkmar N, Thezenas M-L, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC (2018) The ER membrane protein complex (EMC) promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. Journal of Cell Science doi: 10.1242/jcs.223453. PMID 30578317 PDF

112. Fernandez RF, Kim SQ, Zhao Y, Foguth RM, Weera MM, Counihan JL, Nomura DK, Chester JA, Cannon JR, Ellis JM (2018) Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acidDHA in the brain. Proceedings of the National Academy of Sciences, U.S.A. 115, 12525-12530. PMID 30327559 PDF

111. Zhou M, Ford B, Lee D, Huen K, Tran Y, Bradman A, Gunier R, Eskenazi B, Nomura DK, Holland NT (2018) Metabolomic markers of phthalate exposure in plasma and urine of pregnant women. Frontiers in Public Health 6, 298. PMID 30406068 PDF

110. Nomura DK* and Maimone TJ*. (2018) Target identification of bioactive covalently-acting natural products. Current Topics in Microbiology and Immunology 420, 351-374. PMID 30105423 (*co-corresponding authorship) PDF

109. Nomura DK (2018) Virtual Issue on the Work of John Casida. Chemical Research in Toxicology 31, 637-638. PMID 30080400 PDF

108. Counihan JL*, Wiggenhorn A*, Anderson KE, Nomura DK. (2018) Chemoproteomics-enabled covalent ligand screening reveals ALDH3A1 as a lung cancer target. ACS Chemical Biology 13, 1970-1977. PMID 30004670 (*co-first authors) PDF

107. Wallace M, Green CR, Roberts LS, Lee YM, McCarville J, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover J, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM (2018) Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nature Chemical Biology 14, 1021-1031. PMID 30327559 PDF

106. Counihan JL, Grossman EA, Nomura DK. (2018) Cancer metabolism: current understanding and therapies. Chemical Reviews 118, 6893-6923. PMID 29939018 PDF

105. Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka T, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM. (2018) Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception. PNAS 115, E6937-E6945. PMID 29967167 PDF

104. Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA. (2018) Global proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoforms. Developmental Cell 46, 219-235. PMID 30016623 PDF

103. Tam AB, Roberts LS, Chandra V, Rivera IG, Nomura DK, Forbes DJ, Niwa M. (2018) The UPR activator ATF6 responds to proteotoxic and lipotoxic stress by distinct mechanisms. Developmental Cell 46, 327-343. PMID 30086303 PDF

102. Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Fernandez-del Castillo C, Nomura DK, Haas W, Bardeesy N. (2018) Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nature Cell Biology 20, 811-822. PMID 29941929 PDF

101. Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW. (2018) Regulation of hepatic lipid accumulation and distribution by Agouti-relation protein in male mice. Endocrinology 159, 2408-2420. PMID 29750244 PDF

100. Lin H, Long JZ, Roche AM, Svensson KJ, Dou F, Chang MR, Srutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM. (2018) Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogs that stimulate mitochondrial respiration. Journal of Medicinal Chemistry 61, 3224-3230. PMID 29533650 PDF

99. Tomin T, Fritz K, Gindlhuber J, Waldherr L, Pucher B, Thallinger GG, Nomura DK, Schittmayer M, Birner-Gruenberger R. (2018) Deletion of adipose triglyceride lipase links triacylglycerol accumulation to a more aggressive phenotype in A549 lung carcinoma cells. Journal of Proteome Research 17, 1415-1425. PMID 29457907 PDF

98. Prasse C, Ford B, Nomura DK, Sedlak DL. (2018) Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. Proceedings of the National Academy of Sciences, USA. Doi: 10.1073/pnas.1715821115. PMID 29463747 PDF

97. Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Ballus TE, Nomura DK, Burke JE, Shokat KM, London N. (2018) Novel K-Ras G12C switch-II covalent binders destabilize Ras and accelerate nucleotide exchange. Journal of Chemical Information and Modeling 57, 464-471. PMID 29320178 PDF

96. Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R. (2018) Paternal chromosome loss and metabolic collapse result in Xenopus hybrid inviability. Nature 553, 337-341. PMID: 29320479 PDF

95. Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA. (2017) A promixity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes. Developmental Cell 44, 97-112. PMID 29275994 PDF


94. De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo Z-Q, Vance RE. (2017) Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectors. Cell Reports 21, 2031-2038. PMID 29166595 PDF

93. Lue JW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburh KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, Anderson KE, Evans MJ, O’Donnell VB, Nomura DK, Drake JM, Ritz A, Thomas GV. (2017) Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes and Development 31, 2067-2084. PMID 29138276 PDF

92. Grossman E*, Ward CC*, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK. (2017) Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products. Cell Chemical Biology doi:10.1016/j.chembiol.2017.08.013. PMID 28919038 (*co-first authorship) PDF

91. Anderson KE, To M, Olzmann JA, Nomura DK. (2017) Chemoproteomics-enabled covalent ligand screening reveals a thioredoxin-caspase 3 interaction disruptor that impairs breast cancer pathogenicity. ACS Chemical Biology doi: 10.1021/acschembio.7b00711. PMID 28892616 PDF

90. Chen T-C, Benjamin DI, Kuo T, Lee RA, Li M-L, Mar D, Costello DE, Nomura DK, Wang J-C. (2017) Glucocorticoid-Angiopoietin-like 4-Ceramide Axis induces insulin resistance. Science Signaling 10, eaai7905. PMID 28743803. PDF

89. Chomvong K, Benjamin DI, Nomura DK, Cate JH. Cellobiose consumption uncouples extracellular glucose sensing and glucose metabolism in Saccharomyces cerevisiae. mBio 8, e00855-17. PDF

88. Nguyen TB, Louie SM, Daniele J, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. (2017) DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy. Developmental Cell 42, 9-21. PMID 28697336 PDF

87. Ward CC, Kleinman J, Nomura DK. (2017) NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspots. ACS Chemical Biology 12, 1478-1483. PMID 28445029 PDF

86. Bateman LA#, Nguyen TB#, Roberts AM#, Miyamoto DK, Ku W-M, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA*, Nomura DK*. (2017) Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in Reticulon 4 that impairs ER morphology and cancer pathogenicity. Chemical Communications 53, 7234-7237. PMID 28352901 (#co-first authors; *co-corresponding author) PDF

85. Castellano, B.M., Thelen, A.M., Moldavski O, Feltes M, van der Welle R, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey D, Nomura DK, Ory DS, Zoncu R. (2017) Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann Pick C1 signaling complex. Science 355, 1306-1311. PMID 28336668 PDF

84. Roberts LS, Yan P, Bateman LA, Nomura DK. (2017) Mapping novel metabolic nodes targeted by anti-cancer drugs that impair triple-negative breast cancer pathogenicity. ACS Chemical Biology 12, 1133-1140. PMID 28248089 PDF

83. Bateman LA, Ku W-M, Heslin MJ, Contrearas CM, Skibola CF, Nomura DK. (2017) ASS1 is an important metabolic regulator of colorectal cancer. ACS Chemical Biology 12, 905-911. PMID 28229591 PDF

82. Roberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Akopian D, Heslin MJ, Contreras CM, Rape M, Skibola CF, Nomura DK. (2017) Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target. ACS Chemical Biology 12, 899-904. PMID 28186401 PDF

81. Counihan JL, Duckering M, Dalvie E, Ku W-m, Bateman LA, Fisher KJ, Nomura DK. (2017) Mapping proteome-wide reactivity of the widely used herbicide acetochlor in mice. ACS Chemical Biology 12, 635-642. PMID 28094496 PDF

80. Whang MI, Taveras RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. (2017) The ubiquitin binding protein TAX1BP mediates autophagasome induction and the metabolic transition of activated T cells. Immunity 46, 405-420. PMID 28314591 PDF

79. Anderton B, Camarda R, Balkrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A. (2017) MYC-driven inhibition of the glumate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Report 18, 569-585. PMID 28219903 PDF

78. Ford B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK. (2017) Mapping proteome-wide targets of glyphosate in mice. Cell Chemical Biology 24, 133-140. PMID 28132892 PDF

77. Ruby MA, Massart J, Hunerdosse DM, Schonke M, Correia JC, Louie SM, Ruas JL, Naslund E, Nomura DK, Zierath JR. (2017) Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance. Cell Reports 18, 636-646. PMID 28099843 PDF

76. To M, Peterson CWH, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA. (2017) Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation. Molecular Biology of the Cell 28, 270-284. PMID 27881664 PDF

75. Roberts AM, Ward CC, Nomura DK. (2017) Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots. Current Opinion in Biotechnology 43, 25-33. PMID 27568596 PDF


74. Kim H-E, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff Suzanne, Dillin A (2016) Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response. Cell 166, 1539-1552. PMID 27568596 PDF

73. Sogi K, Holsclaw C, Fragiadakis G, Nomura DK, Leary J, Bertozzi C. (2016) Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis. ACS Infectious Diseases 2, 800-806. PMID 27933784 PDF

72. Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA. (2016) HIF-1alpha is an essential mediator of IFA-gamma-dependent immunity to Mycobacterium tuberculosis. Journal of Immunology doi: 10.4049/jimmunol.1600266. PMID 27430718 PDF

71. Kohnz RA, Roberts, LS, DeTomaso D, Badyopadhyay S, Yosef N, Nomura DK. (2016) Protein sialylation regulates a gene expression signature that promotes breast cancer cell pathogenicity. ACS Chemical Biology 11, 2131-2139. PMID 27380425 PDF

70. Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MT, Jedrychowski MP, Paolo J, Griffin PR, Nomura DK*, Spiegelman BM* (2016) PM20D1 secretion by thermogenic adipose cells regulates lipidated amino acid uncouplers of mitochondrial respiration. Cell 166, 424-435. PMID 27374330 (*co-corresponding authorship) PDF

69. Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JHD. (2016) Bypassing the pentose phosphate pathway: Towards modular utilization of xylose. Plos One 11, e0158111. PMID 27336308 PDF

68. Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK. (2016) GSTP1 is a driver of triple-negative breast cancer cell metabolism and pathogenicity. Cell Chemical Biology 23, 1-12. PMID 27185638 PDF

67. Nomura DK, Casida JE (2016) Lipases and their inhibitors in health and disease. Chemico-Biological Interactions doi: 10.1016/j.cbi.2016.04.004. PMID 27067293 PDF

66. Zhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola C (2016) The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma. Oncoscience 3, 31-41. PMID 26973858 PDF

65. Nikkanen J, Forsstrom S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamaki J, Roivainen A, Marjamaki P, Liljenback H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lonnqvist T, Sajantila A, Isohanni P, Tyynaismaa H, Nomura DK, Battersby B, Velagapudi V, Carroll CJ, Suomalainen A (2016) Mitochondrial DNA replication defects disturb cellular dNTP pools and remodel one-carbon metabolism. Cell Metabolism 23, 635-648. PMID 26924217 PDF

64. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. (2016) Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nature Medicine 22, 427-432. PMID 26950360. PDF

63. Saghatelian A, Nomura DK, Weerapana E (2016) Omics: The maturation of chemical biology. Current Opinions in Chemical Biology 30: v-vi. PMID 26739665 PDF

62. Counihan JC, Ford B, Nomura DK. (2016) Mapping Proteome-Wide Interactions of Reactive Chemicals using Chemoproteomic Platforms. Current Opinions in Chemical Biology 30, 68-76. PMID 26647369 PDF


61. Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK. (2015) Mapping Proteome-Wide Targets of Environmental Chemicals using Reactivity-Based Chemoproteomic Platforms. Chemistry & Biology 22, 1394-1405. PMID 26496688 PDF

60. Piano V#, Benjamin DI#, Valente S, Nenci S, Mai A, Aliverti A, Nomura DK*, Mattevi A*. (2015) Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents. ACS Chemical Biology doi: 10.1021/acschembio.5b00466. PMID 26322624 (# equal contribution; * co-corresponding authors). PDF

59. Queiroz A, Medina-Cleghorn D, Marjanovic O, Nomura DK, Riley LW. (2015) Comparative metabolic profiling of Mycobacterium tuberculosis: cell wall lipid reorganization as a virulence factor. Pathogens and Disease pii: ftv066. PMID26319139. PDF

58. Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B. (2015) Monoacylglycerol lipase regulates fever response. PLoS One. 10, e0134437. PMID: 26287872 PDF

57. Kohnz RA, Mulvihill MM, Chang JW, Hsu K-L, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK. (2015) Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. ACS Chemical Biology 10, 1624-1630 PMID: 25945974 PDF

56. Benjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK. (2015) Diacylglycerol metabolism and signaling is a predictive and driving force underlying FASN inhibitor sensitivity in cancer cells. ACS Chemical Biology 10, 1616-1623. PMID: 25871544 PDF

55. Rashidian J, Le Scolan E, Ji X, Mulvihill MM, Nomura DK, Luo K. (2015) Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Science Signaling 10, ra14. PMID: 25670202 PDF

54. Anderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RLS, Quinlan CL, Ng R, Jastroch, M, Benjamin DI, Nie B, Herber C, Van A-AN, Park MK, Yun D, Chan K, Yu A, Vuong P, Febbraio M, Nomura DK, Napoli JL, Brand MD, Stahl A. (2015) Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake. Cell Reports 10, 505-515. PMID: 25620701 PDF

53. Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu K-L, Cravatt BF. (2015) A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chemical Biology 10, 925-32. PMID: 25602368 PDF


52. Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RAB, Kleschevnikov AM. (2014) Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in aged Ts65Dn mice, a model of Down Syndrome. Plos One 9, e114521. PMID: 25474204 PDF

51. Valdearcos M, Robblee M, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. (2014) Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function. Cell Reports 9, 1-15. PMID: 25497089 PDF

50. Hunerdosse D, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh J, Zhong S, Nomura DK. (2014) Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target. ACS Chemical Biology. Doi: 10.1021/cb500717g. PMID: 25343321. PDF

49. Medina-Cleghorn D, Nomura DK. (2014) Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms. Chemistry & Biology 21, 1171-1184. PMID: 25237861. PDF

48. Mulvihill MM, Nomura DK. (2014) Metabolomic Strategies to Map Functions of Metabolic Pathways. AJP Metabolism and Endocrinology 307, E237-E244. PMID: 24918200 PDF

47. Latimer LN, Lee MR, Medina-Cleghorn D, Kohnz RA, Nomura DK, Dueber JE. (2014) Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae. Metabolic Engineering 25, 20-29. PMID: 24930894. PDF

46. Mulvihill MM, Benjamin DI, LeScolan E, Ji X, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK. (2014) Metabolic Profiling Reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Chemistry & Biology 21, 831-840. PMID: 24954006 PDF

45. Benjamin DI, Louie S, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandhyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng-SW, Nomura DK. (2014) INPP1 Promotes Cancer Aggressiveness by Linking Inositol Phosphate Recycling to Glycolytic and Lipid Metabolism. ACS Chemical Biology 20, 1340-1350. PMID: 24738946 PDF

44. Kohnz RK, Nomura DK. (2014) Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. Chemical Society Reviews 43, 6859-6869. PMID: 24676249 PDF

43. Morris PJ*, Medina-Cleghorn D*, Heslin A, King S, Orr J, Krauss RM, Nomura DK. (2014) Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. ACS Chemical Biology 9, 1097-1103. (*authors contributed equally to the work) PMID: 24597639 PDF

42. Hunerdosse D, Nomura DK. (2014) Activity-based proteomic and metabolomic approaches for understanding metabolism. Current Opinion in Biotechnology 28C, 116-126. PMID 24594637 PDF

41. Poole D, Lee M, Tso P, Bunnett N, Yo S, Lieu T, Shiu A, Wang J-C, Nomura DK, and Aponte GW. (2014) Feeding dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system. AJP-Gastrointestinal and Liver Physiology 306, G686-G698. PMID: 24578341 PDF

40. Dominguez E, Galmozzi A, Chang JW, Hsu K-L, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O’Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. (2014) Integrated phenotypic screening and activity-based proteomics defines a role for carboxylesterase 3 in obesity and diabetes. Nature Chemical Biology 10, 113-121. PMID: 24362705 PDF

39. Medina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK. (2014) Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides. ACS Chemical Biology 9, 423-432. PMID: 24205821 PDF


38. Nomura DK, Cravatt BF. (2013) Lipid Metabolism in Cancer. Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids 1831, 1497-1498. PMID: 23921253 PDF

37. Benjamin DI, Cozzo A, Ji X, Roberts LS, Louie SM, Luo K, Nomura DK. (2013) The ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids that fuel cancer pathogenicity. Proceedings of the National Academy of Sciences, USA 110, 14912-14917. PMID: 23980144 PDF

36. Louie SM*, Roberts LS*, Mulvihill MM, Luo K, Nomura DK. (2013) Cancer cells incorporate and remodel exogenous fatty acids into structural and oncogenic signaling lipids. Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids 1831, 1566-1572. PMID: 23872477 (* authors contributed equally to the work) PDF

35. Louie SM, Roberts LS, Nomura DK. (2013) Mechanisms linking obesity and cancer. Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids 1831, 1499-1508. PMID: 23470257 PDF

34. Medina-Cleghorn D, Nomura DK. (2013) Chemical Approaches to Study Metabolic Networks. Pflugers Archive 465,427-440. PMID: 23296751 PDF

33. Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdelyi K, Hao E, Holovac E, Hasko G, Cravatt BF, Nomura DK#, Pal Pacher#. (2013) Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology 144, 808-817. PMID: 23295443 (# co-corresponding authors) PDF

32. Mulvihill MM, Nomura DK. (2013) Therapeutic Potential of Monoacylglycerol Lipase Inhibitors. Life Sciences 92, 492-497. PMID: 23142242 PDF


31. Morrison BE, Garibaldi Marcondes MC, Nomura DK, Sanchez-Alavez M, Saar I, Bartfai T, Maher P, Sugama S, Conti B. (2012) IL-13Ralpha1 expression in dopaminergic neurons contributes to their oxidative stress-mediates loss following chronic systemic treatment with LPS. Journal of Immunology 189, 5498-5502. PMID: 23169588 PDF

30. Benjamin DI, Cravatt BF, Nomura DK. (2012) Global Profiling Strategies towards Mapping Dysregulated Metabolic Pathways in Cancer. Cell Metabolism 16, 565-567. PMID: 23063552 PDF

29. Piro JR, Benjamin DI, Duerr JM, Pi YQ, Gonzales C, Schwartz JW, Nomura DK#, Samad TA#. (2012) A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer’s Disease. Cell Reports 1, 617-623. PMID: 22813736 (# co-corresponding author) PDF


28. Nomura DK#, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF#. (2011) Endocannabinoid hydrolysis generates brain eicosanoids that promote neuroinflammation. Science 334, 809-813. PMID: 22021672 (# co-corresponding author) PDF

27. Ruby MA, Nomura DK, Hudak CSS, Barber A, Casida JE, Krauss RM. (2011) Overactive endocannabinoid signaling induces hepatic steatosis, insulin resistance, and global transcriptional changes. Plos One 6, e26415. PMID: 22073164 PDF

Undergraduate, Graduate, Postdoctoral Work (2002-2011)


26. Nomura DK#, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF#. (2011) Monoacylglycerol lipase exerts bidirectional control over endocannabinoid and fatty acid pathways to support prostate cancer pathogenesis. Chemistry & Biology 18, 848-856. PMID: 21802006 (# co-corresponding author) PDF

25. Ramesh D, Ross GR, Schlosburg JE, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF. (2011) Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated withdrawal symptoms in mice. Journal of Pharmacology and Experimental Therapeutics 339, 173-185. PMID: 21719468 PDF

24. Kinsey SG, Nomura DK, O’Neal ST, Long JZ, Cravatt BF, Lichtman AH. (2011) Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice. Journal of Pharmacology and Experimental Therapeutics 338, 795-802. PMID: 21659471 PDF

23. Chang JW, Nomura DK, Cravatt BF. (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chemistry & Biology 18, 476-484. PMID: 21513884 PDF

22. Ahn K, Smith SE, Liimata MB, Sadagopan N, Dudley D, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stif C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF. (2011) Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain. Journal of Pharmacology and Experimental Therapeutics 338, 114-124. PMID: 21505060 PDF

21. Nomura DK#, Casida JE#. (2011) Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple secondary targets in the mammalian nervous system. Journal of Agricultural and Food Chemistry 59, 2808-2815. PMID: 21341672 (# co-corresponding author) PDF

20. Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu R, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR. (2011) Design, synthesis and biological evaluation of a biyouyanagin compound library. Proceedings of the National Academy of Sciences, USA 108, 6715-6720. PMID: 21245351 PDF

19. Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schűrer, Nomura DK, Rosen H, Fu GC, Cravatt BF. (2011) Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences, USA 108, 6811-6816. PMID: 21398589 PDF


18. Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Simon GM, Cravatt BF. (2010) The glycerophospho-metabolome and its influence on amino acid homeostasis by brain metabolomics of GDE1(-/-) mice. Chemistry & Biology 17, 831-840. PMID: 20797612 PDF

17. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Nguyen PT, Ramesh D, Kinsey SG, Booker L, Burston JK, Wise LE, Ghosh S, Selley DE, Sim-Selley LJ, Liu Q, Cravatt BF, Lichtman AH. (2010) Sustained inactivation of monoacylglycerol lipase produces functional antagonism of the brain endocannabinoid system. Nature Neuroscience 13, 1113-1119. PMID: 20729846 PDF

16. Nomura DK, Dix MM, Cravatt BF. (2010) Chemoproteomic Approaches for Biochemical Pathway Discovery in Cancer. Nature Reviews Cancer 10, 630-638. PMID: 20703252 PDF

15. Nomura DK, Long JZ, Niessen S, Hoover HS, Ng S-W, Cravatt BF. (2010) Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140, 49-61. PMID: 20079333 PDF


14. Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF. (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences, USA 106, 20270-20275. PMID: 19918051 PDF

13. Long JZ, Nomura DK, Cravatt BF. (2009) Mechanistic characterization of selective monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chemistry & Biology 16, 744-753. PMID: 19635411 PDF


12. Ruby M*, Nomura DK*, Hudak CS, Mangravite LM, Chiu S, Casida JE, Krauss RM. (2008) Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proceedings of the National Academy of Sciences, USA 105, 14561-14566. PMID: 18794527 (* co-first author) PDF

11. Nomura DK, Ward AM, Hudak CS, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman A, Casida JE. (2008) Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorganic Medicinal Chemistry Letters 18, 5875-5878. PMID: 18752948 PDF

10. Casida JE, Nomura DK, Vose SC, Fujioka K. (2008) Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and Endocannabinoids. Chemico-Biological Interactions 175, 355-64. PMID: 18495101 PDF

9. Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008) Activation of the endocannabinoid system by organophosphorus nerve agents. Nature Chemical Biology 4, 373-378. PMID: 18438404 PDF

8. Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008) Dual Roles of Brain Serine Hydrolase KIAA1363 in Ether Lipid Metabolism and Organophosphate Detoxification. Toxicology and Applied Pharmacology 228, 42-482. PMID: 18154358 PDF


7. Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2006) Serine Hydrolase KIAA1363: Toxicological and Structural Features with Emphasis on Organophosphate Interactions. Chemical Research in Toxicology 19, 1142-1150. PMID: 16978018 PDF

6. Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE. (2006) Each Lipase has a Unique Sensitivity Profile for Organophosphorus Inhibitors. Toxicological Sciences 91,166-172. PMID: 16449251 PDF


5. Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2005) A Brain Detoxifying Enzyme for Organophosphorus Nerve Poisons. Proceedings of the National Academy of Sciences, USA 102, 6195-6200. PMID: 15840715 PDF


4. Segall Y, Quistad GB, Sparks SE, Nomura DK, Casida JE. (2003) Toxicological and Structural Features of Organophosphorus and Organosulfur Cannabinoid CB1 Receptor Ligands. Toxicological Sciences 76, 131-137. PMID: 12944568 PDF

3. Segall Y, Quistad GB, Nomura DK, Casida JE. (2003) Arachidonylsulfonyl Derivatives as Cannabinoid CB1 Receptor and Fatty Acid Amide Hydrolase Inhibitors. Bioorganic Medicinal Chemistry Letters 13,3301-3303. PMID: 12951114 PDF


2. Quistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE. (2002) Cannabinoid CB1 Receptor as a Target for Chlorpyrifos Oxon and Organophosphorus Pesticides. Toxicology Letters 135, 89-93. PMID: 12243867 PDF

1. Quistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE. (2002) Selective Inhibitors of Fatty Acid Amide Hydrolase Relative to Neuropathy Target Esterase and Acetylcholinesterase: Toxicological Implications. Toxicology and Applied Pharmacology 179, 57-63. PMID: 11884237 PDF


Cravatt BF, Nomura DK, Chang JW, Moellering M, Bachovchin, D, Li, W. (2011) Anti-cancer serine hydrolase inhibitory carbamates. PCT/US2011/057321 PDF

Cravatt BF, Long JZ, Li W, Nomura DK. (2010) Methods and Compositions Related to Targeting Monoacylglycerol Lipase. US Patent 8772318; PCT/US2009/006045. PDF