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Rational Chemical Design of Molecular Glue Degraders Toriki ES*, Papatzimas JW*, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song J-G, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-kB King EA, Cho Y, Hsu, NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Targeted Protein Degradation through E2 Recruitment Forte N, Dovala D, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Ligandability of E3 Ligases for Targeted Protein Degradation Applications Belcher B, Ward CC, Nomura DK
Advances in covalent drug discovery Boike L*, Henning NJ*, Nomura DK
Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization Henning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications Henning NJ*, Manford AG*, Spradlin JN, Brittain SM, Zhang E, McKenna JM, Tallarico JA, Schirle M, Rape M#, Nomura DK#
Reimagining Druggability using Chemoproteomic Platforms Spradlin JN, Zhang E, Nomura DK
Chemoproteomics-enabled ligand discovery of covalent RNF114-based degraders that mimic natural product function Luo M*, Spradlin JN*, Boike L, Tong B, Brittain SM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#.
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC Boike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Manumycin polyketides act as molecular glues between UBR7 and P53 Isobe Y, Okumura M, White R, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone TJ*, Nomura DK*
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition Chung CY-S*, Shin HR*, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R#, Nomura DK#
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK*
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK 2023
Covalent targeting of glutamate cysteine ligase to inhibit glutathione synthesis Zhang L, Tang M, Tao X, Shao Q, Thomas V, Shimizu S, Kasano M, Ishikawa Y, Inukai T, Nomura DK N-acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics Koo T-Y, Lai H, Nomura DK, Chung CY-K.
A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication Han H, Gracia AV, Roise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N.
Ophiobolin A covalently targets complex IV leading to mitochondrial metabolic collapse in cancer cells. Gowans FA, Thach DQ, Wang Y, Altamirano Poblano BE, Dovala D, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK* BioRxiv. 2023, doi: https://doi.org/10.1101/2023.03.09.531918.
Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging Benjamin DI, Brett JO, Both P, Benjamin JS, Ishak HL, Kang J, Kim S, Chung M, Arjona M, Nutter CW, Tan JH, Krishnan AK, Dulay H, Louie SM, de Morree A, Nomura DK, Rando TA
Rational Chemical Design of Molecular Glue Degraders Toriki ES*, Papatzimas JW*, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song J-G, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-kB King EA, Cho Y, Hsu, NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Targeted Protein Degradation through E2 Recruitment Forte N, Dovala D, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Discovery of potent pyrazoline-based covalent SARS-CoV-2 main protease inhibitors Moon P*, Zammt CM*, Shao Q*, Dovala D*, Boike L*, Henning NJ*, Knapp M*, Spradlin JN*, Ward CC*, Wolleb H*, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD#, Nomura DK#
Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3 Belcher BP, Machicao PA, Tong B, Ho E, Friedli J, So B, Bui H, Isobe Y, Maimone TJ#, Nomura DK#
Ligandability of E3 Ligases for Targeted Protein Degradation Applications Belcher B, Ward CC, Nomura DK 2022
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1 Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim C-Y, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R
Advances in covalent drug discovery Boike L*, Henning NJ*, Nomura DK
Tyrosinase-Mediated Synthesis of Nanobody-Cell Conjugates Maza JC, Garcia-Almedina DM, Boike LE, Hamlish NX, Nomura DK, Francis MB
Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling Benjamin DI, Both P, Benjamin JS, Nutter CW, Tan JH, Kang J, Machado LA, Klein JDD, de Morree A, Kim S, Liu L, Dulay H, Feraboli L, Louie SM, Nomura DK, Rando TA
Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design Page ACS, Scholz SO, Keenan KN, Spradlin JN, Belcher BP, Brittain SM, Tallarico JA, McKenna JM, Schirle M, Nomura DK*, Toste FD*
Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization Henning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications Henning NJ*, Manford AG*, Spradlin JN, Brittain SM, Zhang E, McKenna JM, Tallarico JA, Schirle M, Rape M#, Nomura DK# 2021
Reimagining Druggability using Chemoproteomic Platforms Spradlin JN, Zhang E, Nomura DK
Chemoproteomics-enabled ligand discovery of covalent RNF114-based degraders that mimic natural product function Luo M*, Spradlin JN*, Boike L, Tong B, Brittain SM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#.
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC Boike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Chemical investigations into the biosynthesis of the gymnastatin and dankastatin alkaloids Tong B, Belcher BP, Nomura DK, Maimone TJ
Advances and opportunities in targeted protein degradation Nomura DK, Dey M
De novo design of SARS-CoV-2 Main Protease Inhibitors Trauner D, Fischer C, Nynke V, Peitsinis Z, Ruhmann P, Yang C, Spradlin J, Dovala D, Nomura D, Zhang Y
CYP27A1 dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism Cho H, Shen Q, Zhang LH, Okumura M, Kawakami A, Ambrose J, Sigoillot F, Miller HR, Gleim S, Cobos-Correa A, Wang Y, Piechon P, Roma G, Eggiman F, Moore C, Aspesi Jr. P, Mapa FA, Burks H, Ross NT, Krastel P, Hild M, Maimone TJ, Fisher DE, Nomura DK, Tallarico JT, Canham SM, Jenkins JL, Forrester WC
Mitohormesis reprograms macrophage metabolism to enforce tolerance Timblin GA, Tharp KM, Ford B, Winchenster JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, ten Hoeve J, Nomura DK, Stahl A, Saijo K
Oncogene regulated release of extracellular vesicles Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohn RA, Avsaroglu B, L’Etoile ND, Perera RM, Nomura DK, Goga A
Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2 Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze Gahmen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. ACS Infectious Diseases, 2021, 7, 2337-2351. PMID 34129317
Adhesion-mediated mechanosignaling forces mitohormesis Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saiko K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM.
4beta-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor. Moldavski O, Zushin P-JH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey SF, Nomura DK, Stahl A, Weiss EJ, Zoncu R
Lipidome-based targeting of STAT3-driven breast cancer cells using poly-L-glutamic acid-coated layer-by-layer nanoparticles Tosic I, Heppler LN, Egusquiaguirre SP, Boehnke N, Correa S, Costa DF, Grossman EA, Pal S, Richardson D, Ivanov AR, Haas-Kogan DA, Nomura DK, Hammond PT, Frank DA. 2020
Bardoxolone Conjugation Enables Targeted Protein Degradation of BRD4 Tong B*, Luo M*, Xie Y, Spradlin JN, Tallarico JA, McKenna JM, Schirle M, Maimone TJ#, Nomura DK#
Manumycin polyketides act as molecular glues between UBR7 and P53 Isobe Y, Okumura M, White R, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone TJ*, Nomura DK*
A nimbolide-based kinase degrader preferentially degrades oncogenic BCR-ABL Tong B*, Spradlin JN*, Novaes LFT, Zhang E, Hu X, Moeller M, Brittain SM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication Sponton CH, Hosonoro T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradham R, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokohama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S
Unbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in small cell lung cancer stem cells Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Korgan N, Jackson PK, Narla G, Gordan JD, Shokat K, Sage J
Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vihelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW
A cellular mechanism to detect and alleviate reductive stress Manford AG, Rodriguez-Perez F, Shih KY, Shi Z, Berdan CB, Choe M, Titov DV, Nomura DK, Rape M 2019
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition Chung CY-S*, Shin HR*, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R#, Nomura DK#
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK*
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK
Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells Berdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ*, Nomura DK*
A metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity to the statin class of host-targeted therapeutics Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C Lim C-Y, Davis O, Shin H, Zhang J, Berdan CB, Jiang X, Counihan JL, Ory D, Nomura DK, Zoncu R
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism Lee K, Yesilkanal AE, Wynne JP, Frakenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomer MK, Parpargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA
Exogenous monounsaturated fatty acids suppress non-apoptotic cell death Magtanong L, Ko P-J, To M, Cao JY, Tarangelo AN, Ward CC, Cho KY, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ
Development of alky glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-to-mesechymal transition in cancer cells Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S
The ER membrane protein complex (EMC) promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis Volkmar N, Thezenas M-L, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC 2018
Virtual Issue on the Work of John Casida Nomura DK
Cancer metabolism: current understanding and therapies Counihan JL, Grossman EA, Nomura DK
Chemoproteomics-enabled covalent ligand screening reveals ALDH3A1 as a lung cancer target Counihan JL*, Wiggenhorn A*, Anderson KE, Nomura DK
Target identification of bioactive covalently-acting natural products Nomura DK* and Maimone TJ*
Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka T, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM
Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain Fernandez RF, Kim SQ, Zhao Y, Foguth RM, Weera MM, Counihan JL, Nomura DK, Chester JA, Cannon JR, Ellis JM
Metabolomic markers of phthalate exposure in plasma and urine of pregnant women Zhou M, Ford B, Lee D, Huen K, Tran Y, Bradman A, Gunier R, Eskenazi B, Nomura DK, Holland NT
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues Wallace M, Green CR, Roberts LS, Lee YM, McCarville J, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover J, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM
The UPR activator ATF6 responds to proteotoxic and lipotoxic stress by distinct mechanisms Tam AB, Roberts LS, Chandra V, Rivera IG, Nomura DK, Forbes DJ, Niwa M
Regulation of hepatic lipid accumulation and distribution by Agouti-relation protein in male mice Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW
Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogs that stimulate mitochondrial respiration Lin H, Long JZ, Roche AM, Svensson KJ, Dou F, Chang MR, Srutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM
Deletion of adipose triglyceride lipase links triacylglycerol accumulation to a more aggressive phenotype in A549 lung carcinoma cells Tomin T, Fritz K, Gindlhuber J, Waldherr L, Pucher B, Thallinger GG, Nomura DK, Schittmayer M, Birner-Gruenberger R
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light Prasse C, Ford B, Nomura DK, Sedlak DL
Novel K-Ras G12C switch-II covalent binders destabilize Ras and accelerate nucleotide exchange Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Ballus TE, Nomura DK, Burke JE, Shokat KM, London N
Paternal chromosome loss and metabolic collapse result in Xenopus hybrid inviability Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R
A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA
Global proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoforms Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA
Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Fernandez-del Castillo C, Nomura DK, Haas W, Bardeesy N 2017
Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products Grossman E*, Ward CC*, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK
Chemoproteomics-enabled covalent ligand screening reveals a thioredoxin-caspase 3 interaction disruptor that impairs breast cancer pathogenicity Anderson KE, To M, Olzmann JA, Nomura DK
NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspots Ward CC, Kleinman J, Nomura DK
Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in Reticulon 4 that impairs ER morphology and cancer pathogenicity Bateman LA#, Nguyen TB#, Roberts AM#, Miyamoto DK, Ku W-M, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA*, Nomura DK*
Mapping novel metabolic nodes targeted by anti-cancer drugs that impair triple-negative breast cancer pathogenicity Roberts LS, Yan P, Bateman LA, Nomura DK
ASS1 is an important metabolic regulator of colorectal cancer Bateman LA, Ku W-M, Heslin MJ, Contrearas CM, Skibola CF, Nomura DK
Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target Roberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Akopian D, Heslin MJ, Contreras CM, Rape M, Skibola CF, Nomura DK
Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots Roberts AM, Ward CC, Nomura DK
Mapping proteome-wide reactivity of the widely used herbicide acetochlor in mice Counihan JL, Duckering M, Dalvie E, Ku W-m, Bateman LA, Fisher KJ, Nomura DK
Mapping proteome-wide targets of glyphosate in mice Ford B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK
DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy Nguyen TB, Louie SM, Daniele J, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA
The ubiquitin binding protein TAX1BP mediates autophagasome induction and the metabolic transition of activated T cells Whang MI, Taveras RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A
MYC-driven inhibition of the glumate-cysteine ligase promotes glutathione depletion in liver cancer Anderton B, Camarda R, Balkrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A
Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance Ruby MA, Massart J, Hunerdosse DM, Schonke M, Correia JC, Louie SM, Ruas JL, Naslund E, Nomura DK, Zierath JR
Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation To M, Peterson CWH, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA
Cellobiose consumption uncouples extracellular glucose sensing and glucose metabolism in Saccharomyces cerevisiae Chomvong K, Benjamin DI, Nomura DK, Cate JH
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann Pick C1 signaling complex Castellano, B.M., Thelen, A.M., Moldavski O, Feltes M, van der Welle R, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey D, Nomura DK, Ory DS, Zoncu R
Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectors De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo Z-Q, Vance RE
Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade Lue JW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburh KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, Anderson KE, Evans MJ, O’Donnell VB, Nomura DK, Drake JM, Ritz A, Thomas GV
Glucocorticoid-Angiopoietin-like 4-Ceramide Axis induces insulin resistance Chen T-C, Benjamin DI, Kuo T, Lee RA, Li M-L, Mar D, Costello DE, Nomura DK, Wang J-C 2016
PM20D1 secretion by thermogenic adipose cells regulates lipidated amino acid uncouplers of mitochondrial respiration Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MT, Jedrychowski MP, Paolo J, Griffin PR, Nomura DK*, Spiegelman BM*
Protein sialylation regulates a gene expression signature that promotes breast cancer cell pathogenicity Kohnz RA, Roberts, LS, DeTomaso D, Badyopadhyay S, Yosef N, Nomura DK
GSTP1 is a driver of triple-negative breast cancer cell metabolism and pathogenicity Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK
Mapping Proteome-Wide Interactions of Reactive Chemicals using Chemoproteomic Platforms Counihan JC, Ford B, Nomura DK
Lipases and their inhibitors in health and disease Nomura DK, Casida JE
Omics: The maturation of chemical biology Saghatelian A, Nomura DK, Weerapana E
Bypassing the pentose phosphate pathway: Towards modular utilization of xylose Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JHD
HIF-1alpha is an essential mediator of IFN-gamma-dependent immunity to Mycobacterium tuberculosis Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA
Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A
Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis Sogi K, Holsclaw C, Fragiadakis G, Nomura DK, Leary J, Bertozzi C
The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma Zhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola C
Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response Kim H-E, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff Suzanne, Dillin A
Mitochondrial DNA replication defects disturb cellular dNTP pools and remodel one-carbon metabolism Nikkanen J, Forsstrom S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamaki J, Roivainen A, Marjamaki P, Liljenback H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lonnqvist T, Sajantila A, Isohanni P, Tyynaismaa H, Nomura DK, Battersby B, Velagapudi V, Carroll CJ, Suomalainen A 2015
Diacylglycerol metabolism and signaling is a predictive and driving force underlying FASN inhibitor sensitivity in cancer cells Benjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK
Mapping Proteome-Wide Targets of Environmental Chemicals using Reactivity-Based Chemoproteomic Platforms Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents Piano V#, Benjamin DI#, Valente S, Nenci S, Mai A, Aliverti A, Nomura DK*, Mattevi A*
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer Kohnz RA, Mulvihill MM, Chang JW, Hsu K-L, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK
A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu K-L, Cravatt BF
Ski regulates Hippo and TAZ signaling to suppress breast cancer progression Rashidian J, Le Scolan E, Ji X, Mulvihill MM, Nomura DK, Luo K
Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake Anderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RLS, Quinlan CL, Ng R, Jastroch, M, Benjamin DI, Nie B, Herber C, Van A-AN, Park MK, Yun D, Chan K, Yu A, Vuong P, Febbraio M, Nomura DK, Napoli JL, Brand MD, Stahl A
Comparative metabolic profiling of mce1 operon mutant vs wild-type Mycobacterium tuberculosis strains Queiroz A, Medina-Cleghorn D, Marjanovic O, Nomura DK, Riley LW
Monoacylglycerol lipase regulates fever response Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B 2014
Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids Kohnz RK, Nomura DK
Metabolic Profiling Reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity Mulvihill MM, Benjamin DI, LeScolan E, Ji X, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK
INPP1 Promotes Cancer Aggressiveness by Linking Inositol Phosphate Recycling to Glycolytic and Lipid Metabolism Benjamin DI, Louie S, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandhyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng-SW, Nomura DK
Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target Hunerdosse D, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh J, Zhong S, Nomura DK
Metabolomic Strategies to Map Functions of Metabolic Pathways Mulvihill MM, Nomura DK
Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia Morris PJ*, Medina-Cleghorn D*, Heslin A, King S, Orr J, Krauss RM, Nomura DK
Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides Medina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK
Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms Medina-Cleghorn D, Nomura DK
Activity-based proteomic and metabolomic approaches for understanding metabolism Hunerdosse D, Nomura DK
Feeding dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system Poole D, Lee M, Tso P, Bunnett N, Yo S, Lieu T, Shiu A, Wang J-C, Nomura DK, and Aponte GW
Integrated phenotypic screening and activity-based proteomics defines a role for carboxylesterase 3 in obesity and diabetes Dominguez E, Galmozzi A, Chang JW, Hsu K-L, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O’Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E
Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in aged Ts65Dn mice, a model of Down Syndrome Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RAB, Kleschevnikov AM
Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae Latimer LN, Lee MR, Medina-Cleghorn D, Kohnz RA, Nomura DK, Dueber JE
Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function Valdearcos M, Robblee M, Benjamin DI, Nomura DK, Xu AW, Koliwad SK 2013
Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity Benjamin DI, Cozzo A, Ji X, Roberts LS, Louie SM, Luo K, Nomura DK.
Lipid Metabolism in Cancer Nomura DK, Cravatt BF
Cancer cells incorporate and remodel exogenous fatty acids into structural and oncogenic signaling lipids Louie SM*, Roberts LS*, Mulvihill MM, Luo K, Nomura DK
Mechanisms linking obesity and cancer Louie SM, Roberts LS, Nomura DK
Chemical Approaches to Study Metabolic Networks Medina-Cleghorn D, Nomura DK
Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdelyi K, Hao E, Holovac E, Hasko G, Cravatt BF, Nomura DK#, Pal Pacher#
Therapeutic Potential of Monoacylglycerol Lipase Inhibitors Mulvihill MM, Nomura DK 2012
Global Profiling Strategies towards Mapping Dysregulated Metabolic Pathways in Cancer Benjamin DI, Cravatt BF, Nomura DK
A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer’s Disease Piro JR, Benjamin DI, Duerr JM, Pi YQ, Gonzales C, Schwartz JW, Nomura DK#, Samad TA#
IL-13Ralpha1 expression in dopaminergic neurons contributes to their oxidative stress-mediates loss following chronic systemic treatment with LPS Morrison BE, Garibaldi Marcondes MC, Nomura DK, Sanchez-Alavez M, Saar I, Bartfai T, Maher P, Sugama S, Conti B 2011
Overactive endocannabinoid signaling induces hepatic steatosis, insulin resistance, and global transcriptional changes Ruby MA, Nomura DK, Hudak CSS, Barber A, Casida JE, Krauss RM
Endocannabinoid hydrolysis generates brain eicosanoids that promote neuroinflammation Nomura DK#, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF# Postdoctoral, Graduate, and Undergraduate Work 2011
Monoacylglycerol lipase exerts bidirectional control over endocannabinoid and fatty acid pathways to support prostate cancer pathogenesis Nomura DK#, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF#
Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple secondary targets in the mammalian nervous system Nomura DK#, Casida JE#
A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis Chang JW, Nomura DK, Cravatt BF
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain Ahn K, Smith SE, Liimata MB, Sadagopan N, Dudley D, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stif C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schűrer, Nomura DK, Rosen H, Fu GC, Cravatt BF
Design, synthesis and biological evaluation of a biyouyanagin compound library Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu R, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR
Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated withdrawal symptoms in mice Ramesh D, Ross GR, Schlosburg JE, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF
Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice Kinsey SG, Nomura DK, O’Neal ST, Long JZ, Cravatt BF, Lichtman AH 2009
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF
Mechanistic characterization of selective monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism Long JZ, Nomura DK, Cravatt BF 2010
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis Nomura DK, Long JZ, Niessen S, Hoover HS, Ng S-W, Cravatt BF
Chemoproteomic Approaches for Biochemical Pathway Discovery in Cancer Nomura DK, Dix MM, Cravatt BF
Sustained inactivation of monoacylglycerol lipase produces functional antagonism of the brain endocannabinoid system Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Nguyen PT, Ramesh D, Kinsey SG, Booker L, Burston JK, Wise LE, Ghosh S, Selley DE, Sim-Selley LJ, Liu Q, Cravatt BF, Lichtman AH
The glycerophospho-metabolome and its influence on amino acid homeostasis by brain metabolomics of GDE1(-/-) mice Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Simon GM, Cravatt BF 2003
Toxicological and Structural Features of Organophosphorus and Organosulfur Cannabinoid CB1 Receptor Ligands Segall Y, Quistad GB, Sparks SE, Nomura DK, Casida JE
Arachidonylsulfonyl Derivatives as Cannabinoid CB1 Receptor and Fatty Acid Amide Hydrolase Inhibitors Segall Y, Quistad GB, Nomura DK, Casida JE 2005 2006
Serine Hydrolase KIAA1363: Toxicological and Structural Features with Emphasis on Organophosphate Interactions Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE
Each Lipase has a Unique Sensitivity Profile for Organophosphorus Inhibitors Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE 2008
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels Nomura DK, Ward AM, Hudak CS, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman A, Casida JE
Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and Endocannabinoids Casida JE, Nomura DK, Vose SC, Fujioka K.
Activation of the endocannabinoid system by organophosphorus nerve agents Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE
Dual Roles of Brain Serine Hydrolase KIAA1363 in Ether Lipid Metabolism and Organophosphate Detoxification Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE
Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins Ruby M*, Nomura DK*, Hudak CS, Mangravite LM, Chiu S, Casida JE, Krauss RM 2002
Cannabinoid CB1 Receptor as a Target for Chlorpyrifos Oxon and Organophosphorus Pesticides Quistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE
Selective Inhibitors of Fatty Acid Amide Hydrolase Relative to Neuropathy Target Esterase and Acetylcholinesterase: Toxicological Implications Quistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE Patents and Patent Applications
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