Nomura Research Group

Research

Our Team

Publications

Check out our most recent work in @ChemicalBiology - we use Darwinian evolutionary principles to essentially perform thou…

Ingo Hartung @HartungIngo

Many recent papers about #PROTACs, but this may be the most noteworthy one: Increasing tolerability for Bcl-XL targeting w…

MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes cell.com/molecular-cell…

Wang and col. confirm the value of weak E3 ligands! 25 nM and 10 µM VHL chemical handles make equipotent AR-degrading PROTAC…

Ingo Hartung @HartungIngo

Making use of lipophilicity efficiency to prioritize #IRAK4 inhibitor scaffolds by @genentech: A bicyclic lactam scaffold…

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL…

Eric Topol @EricTopol

Time-restricted eating: potential benefits for weight loss, blood pressure, blood lipids in a small study in people w/ metab…

Special issue on protease is finally out @ChemicalBiology! Lots of great articles. Check it out. pubs.acs.org/toc/acbcct/14/…

Chemo- Proteomics

Chemical Biology

Drug Discovery

Nomura

Covalent Ligand Discovery

Natural Product Target Discovery

Induced Proximity Modalities

Nomura

Reimagining Druggability using Chemoproteomic Platforms