One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable.” Our research group is reimagining druggability by using chemoproteomic approaches to tackle the undruggable proteome.
Meet Our Team
We are a group of highly motivated scientists with a desire to engage in multidisciplinary research at the interface of chemistry and biology.
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Happy to showcase our new paper with the Maimone lab and Novartis on Keap1/Nrf2 activator Bardoxolone as a new E3 ligase recruiter for targeted protein degradation applications now out in Scientific Reports! Congrats to grad student Bingqi Tong and postdoc Mai Luo!!
Congrats to chemical biology student Lydia Boike on her paper published in Cell Chemical Biology on a covalent ligand functionally inhibiting MYC by targeting an intrinsically disordered region!!
Congrats to recent MCB-chemical biology Ph.D. graduate Carl Ward for being co-awarded the Nicholas Cozzarelli Prize!!
Congrats to chemical biology graduate student Jessica Spradlin for being awarded the NCI F99/K00 Predoctoral to Postdoctoral Transition Award!!
Our new discovery by postdoc Mai Luo and grad student Jessica Spradlin on a fully synthetic covalent E3 ligase RNF114 recruiter for targeted protein degradation applications on BioRxiv!
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