Our
Research
One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable.” Our research group is reimagining druggability by using chemoproteomic approaches to tackle the undruggable proteome.

Featured Publications
Rational Chemical Design of Molecular Glue Degraders
Toriki ES*, Papatzimas JW*, Nishikawa K, Dovala D, McGregor LM, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK
2022, BioRxiv doi: https://doi.org/10.1101/2022.11.04.512693. (* co-first authorship)
Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization
Henning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Nature Chemical Biology, 2022, 18, 412-421. PMID 35210618 (* co-first authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC
Boike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Cell Chemical Biology, 2021, 28, 4-13. PMID 32966806 (*co-first authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
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