An important new study from a top academic team, the findings could help explain some of the neurological phenomena that have been observed to be associated with SARS-CoV-2 infection. It mirrors findings from some other, similar research. (pre-print) 1/3 https://t.co/zlHu98X0O9

Interesting article! Monomeric #degraders: small molecules mechanism of action might go beyond simply blocking the protein’s activity. Should we be looking for this mechanism more frequently when working with small molecules? https://t.co/G1fpHW0Upd #MedChem #drugs #degraders

Basic science is not at odds with industry science and I don’t understand why they are perceived as competing verticals. Going to industry after my PhD made me a better scientist. We just need to make sure the flow of talent is bidirectional https://t.co/YJB0Y5b8Zw

How are ubiquitin chains extended in a linkage-selective fashion? New structure provides insights into Ube2K mediated K48-chain extension. Multivalent Ub binding recruits Ube2K to ubiquitinated substrates and promotes chain elongation. #enzymeinaction https://t.co/2ggBdl0sXu