RIBOTAC recruits ribonuclease to selectively degrade miRNA target. bit.ly/2I3yFJr bit.ly/30uA1oC #PROTACs…
Chemo- Proteomics
Chemical Biology
Drug Discovery
Covalent Ligand Discovery
Natural Product Target Discovery
Targeted Protein Degradation
A Bounty of New Challenging Targets in Oncology for Chemical Discovery dx.doi.org/10.1021/acs.bi… @kevansf challenge accepte…
Beautiful in vivo demonstration of the molecular ‘AND Gate’ integrating signals that regulate mTORC1. Congrats to Alejo and…
Interesting approach on characterizing PPIs using phage selection. twitter.com/ChemRxiv/statu…
With new method, @UChicago researchers may have found a high-throughput way to detect protein stability changes and “hotspo…
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 | bioRxiv biorxiv.org/content/10.110…
The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex | bioRxiv biorxiv.org/content/10.110…
Defects in the assembly of ribosomes selected for β-amino acid incorporation biorxiv.org/cgi/content/sh… #bioRxiv
Apple is a $950 billion corporation with $250 billion in cash on hand that charges $1,000+ for its new phones. Why should it ge…