Reimagining Druggability

We are reimagining druggability using chemoproteomic platforms to develop transformative medicines.

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One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable.” Our research group is reimagining druggability by using chemoproteomic approaches to tackle the undruggable proteome.

Meet Our Team

We are a group of highly motivated scientists with a desire to engage in multidisciplinary research at the interface of chemistry and biology.

Latest News


Congrats to Mai Luo for starting his position as an Assistant Professor at China Agricultural University

Mai Luo, a former postdoc in our lab that worked on developing new E3 ligase recruiters for targeted protein degradation applications, is starting his new…

Congrats to Mai Luo and Jessica Spradlin for their Cell Chemical Biology paper on a fully synthetic RNF114 ligand for targeted protein degradation applications!

In this paper, we describe the discovery of a fully synthetic covalent ligand EN219 that mimics the action of the more complex natural product nimbolide…

Congrats to Jessica Spradlin for graduating with her PhD from our lab and the chemistry/chemical biology program!

Congrats to Jessica Spradlin for graduating with her PhD in chemical biology! She was instrumental to our lab’s work on expanding the arsenal of E3…

Our work on SARS-CoV-2 and our recent MYC inhibitor story highlighted by Mark Foundation for Cancer Research

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