Nomura Research Group

Research

Our Team

Publications

Our work identifying alpha-ketoglutarate as an effector of p53-mediated tumor suppression, the result of a fantastic collabo…

Stuart Schreiber @SchreiberStuart

Basic biology (senescent cells upregulate beta-Gal) meets basic organic chemistry (unleash a critical cell-killing fun…

London Lab @london_lab

Discovery and optimization of covalent Bcl-xL antagonists sciencedirect.com/science/articl…

Philipp Cromm @PhilippMCromm

Check out the latest perspective from Phil Chamberlain and Lawrence Hamann on protein degradation. Great work! #PROTACs…

Limitations of ligand-only approaches for predicting the reactivity of covalent inhibitors dlvr.it/RDFdw2

Our latest work harnessing Diels-Alder cycloadditions to stabilize diverse peptide structures. This facile chemistry per…

Anticancer properties of a designer peptide, containing a cell penetrating sequence & a p53 mimetic, are mediated by i…

Jordan Meier @doc_jlmeier

Must read! Two immediate comments: 1. The molecules profiled are not straw men (obvious PAINS chemotypes) and on 1st glan…

Interesting work from David Raulet's lab @berkeleyMCB showing that the folate transporter RCF1 also serves as the major t…

Chemo- Proteomics

Chemical Biology

Drug Discovery

Nomura

Covalent Ligand Discovery

Natural Product Target Discovery

Targeted Protein Degradation

Nomura

Reimagining Druggability using Chemoproteomic Platforms