Our
Research
One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable.” Our research group is reimagining druggability by using chemoproteomic approaches to tackle the undruggable proteome.
Featured Publications
Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC
Boike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Cell Chemical Biology, 2020, DOI:https://doi.org/10.1016/j.chembiol.2020.09.001. (*co-first authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
Manumycin polyketides act as molecular glues between UBR7 and P53
Isobe Y, Okumura M, White R, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone TJ*, Nomura DK*
Nature Chemical Biology, 2020, https://doi.org/10.1038/s41589-020-0557-2. PMID 32572277 (*co-corresponding author) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK*
Nature Chemical Biology, 2019, 15, 747-755. PMID 31209351 (*co-corresponding authors) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
Happy to showcase our new paper with the Maimone lab and Novartis on Keap1/Nrf2 activator Bardoxolone as a new E3 ligase recruiter for targeted protein degradation applications now out in Scientific Reports! Congrats to grad student Bingqi Tong and postdoc Mai Luo!!
Congrats to chemical biology student Lydia Boike on her paper published in Cell Chemical Biology on a covalent ligand functionally inhibiting MYC by targeting an intrinsically disordered region!!
Congrats to recent MCB-chemical biology Ph.D. graduate Carl Ward for being co-awarded the Nicholas Cozzarelli Prize!!
Congrats to chemical biology graduate student Jessica Spradlin for being awarded the NCI F99/K00 Predoctoral to Postdoctoral Transition Award!!
Our new discovery by postdoc Mai Luo and grad student Jessica Spradlin on a fully synthetic covalent E3 ligase RNF114 recruiter for targeted protein degradation applications on BioRxiv!
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