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Featured Publications
- Targeted Protein Localization by Covalent 14-3-3 RecruitmentShao Q, Duong TN, Park I, Orr LM, Nomura DK
JACS, 2024, https://doi.org/10.1021/jacs.3c12389. PMID 39196545 - Covalent degrader of the oncogenic transcription factor b-cateninGowans FA*, Forte N*, Hatcher J, Huang OW, Wang Y, Altamirano Poblano BE, Wertz IE, Nomura DK
JACS, 2024, 146, 16856–16865. PMID 38848252 (*co-first authorship) - DCAF16-based covalent handle for the rational design of monovalent degradersLim M*, Do Cong T*, Orr LM, Toriki ES, Kile AC, Lee E, Lin Y, Nomura DK
ACS Central Science, 2024, 10, 1318-1331. PMID 39071058 (*co-first authorship)
(Novartis-Berkeley Translational Chemical Biology Institute paper) - Exploiting the Cullin E3 ligase adaptor protein SKP1 for targeted protein degradationHong SH*, Divakaran A*, Osa A, Huang OW, Wertz IE, Nomura DK
ACS Chemical Biology, 2024, 19, 442-450. PMID 37904950. (*co-first authors) - Targeted protein degradation through recruitment of the CUL4 complex adaptor protein DDB1Meyers M, Cismoski S, Panidapu A, Chie-Leon B, Nomura DK
ACS Chemical Biology, 2024, 19, 58-68. PMID 38192078
(Novartis-Berkeley Translational Chemical Biology Institute paper)
- Rational Chemical Design of Molecular Glue DegradersToriki ES*, Papatzimas JW*, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song J-G, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK
ACS Central Science, 2023, 9, 915-926. (* co-first authorship)
(Novartis-Berkeley Translational Chemical Biology Institute paper) - Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-kBKing EA, Cho Y, Hsu, NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Cell Chemical Biology, 2023, 30, 394-402. PMID 36898369
(Novartis-Berkeley Translational Chemical Biology Institute paper) - Targeted Protein Degradation through E2 RecruitmentForte N, Dovala D, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK
ACS Chemical Biology, 2023, https://doi.org/10.1021/acschembio.3c00040. PMID 36940189
(Novartis-Berkeley Translational Chemical Biology Institute paper)
- Ligandability of E3 Ligases for Targeted Protein Degradation ApplicationsBelcher B, Ward CC, Nomura DK
Biochemistry, 2023, 62, 588-600. PMID 34473924 - Advances in covalent drug discoveryBoike L*, Henning NJ*, Nomura DK
Nature Reviews Drug Discovery, 2022, 21, 881-898. PMID 36008483 (*co-first authors) - Deubiquitinase-Targeting Chimeras for Targeted Protein StabilizationHenning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Nature Chemical Biology, 2022, 18, 412-421. PMID 35210618 (* co-first authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
- Discovery of a covalent FEM1B recruiter for targeted protein degradation applicationsHenning NJ*, Manford AG*, Spradlin JN, Brittain SM, Zhang E, McKenna JM, Tallarico JA, Schirle M, Rape M#, Nomura DK#
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications.
JACS, 2022, 144, 701-708. PMID 34994556 (*co-first authorship; #co-corresponding authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Reimagining Druggability using Chemoproteomic PlatformsSpradlin JN, Zhang E, Nomura DK
Accounts of Chemical Research, 2021, 54, 1801-1813. PMID 33733731 - Chemoproteomics-enabled ligand discovery of covalent RNF114-based degraders that mimic natural product functionLuo M*, Spradlin JN*, Boike L, Tong B, Brittain SM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#.
Cell Chemical Biology, 2021, 28, 559-566. PMID 33513350 (*co-first authorship, # co-corresponding authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYCBoike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Cell Chemical Biology, 2021, 28, 4-13. PMID 32966806 (*co-first authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Manumycin polyketides act as molecular glues between UBR7 and P53Isobe Y, Okumura M, White R, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone TJ*, Nomura DK*
Nature Chemical Biology, 2020, 16, 1189-1198. PMID 32572277 (*co-corresponding author) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibitionChung CY-S*, Shin HR*, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R#, Nomura DK#
Nature Chemical Biology, 2019, 15, 776-785. PMID 31285595 (*co-first authorship; #co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Harnessing the anti-cancer natural product nimbolide for targeted protein degradationSpradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK*
Nature Chemical Biology, 2019, 15, 747-755. PMID 31209351 (*co-corresponding authors) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applicationsWard CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK
ACS Chemical Biology, 2019, 14, 2430-2440. PMID 31059647 (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
2024
- Light-activated reactivity of nitrones with amino acids and proteinsSkakuj K, Iglhaut M, Shao Q, Garcia F, Huang B-Y, Brittain S, Nesvizhskii A, Schirle M, Nomura DK, Toste FD.
Angewandte Chemie International Edition, 2024, doi:10.1002/anie.202415976. PMID 39509590 - Convergent synthesis and protein binding of vicinal difluorides by stereodivergent C-C bond formationQiu Y*, Thomas VCJX*, Fantoni T, Chen R, Jiang X, He Z-T, Butcher TW, Nomura DK**, Hartwig JF**
Chem, 2024, 10, 1–13.
(*co-first authors; **co-corresponding authors) - Targeted Protein Localization by Covalent 14-3-3 RecruitmentShao Q, Duong TN, Park I, Orr LM, Nomura DK
JACS, 2024, https://doi.org/10.1021/jacs.3c12389. PMID 39196545 - X chromosome dosage drives statin-induced dysglycermia and mitochondrial dysfunctionZhang P, Munier JJ, Wiese CB, Vergnes L, Link JC, Abbasi F, Ronquillo E, Scheker K, Munoz A, Kuang Y-L, Theusch E, Lu M, Sanchez G, Oni-Orisan A, Iribarren C, McPhaul MJ, Nomura DK, Knowles JW, Krauss RM, Medina MW, Reue K
Nature Communications, 2024, 15, 5571. Doi:10.1038/s41467-024-49764-2. PMID 38956041 - Covalent degrader of the oncogenic transcription factor b-cateninGowans FA*, Forte N*, Hatcher J, Huang OW, Wang Y, Altamirano Poblano BE, Wertz IE, Nomura DK
JACS, 2024, 146, 16856–16865. PMID 38848252 (*co-first authorship) - DCAF16-based covalent handle for the rational design of monovalent degradersLim M*, Do Cong T*, Orr LM, Toriki ES, Kile AC, Lee E, Lin Y, Nomura DK
ACS Central Science, 2024, 10, 1318-1331. PMID 39071058 (*co-first authorship)
(Novartis-Berkeley Translational Chemical Biology Institute paper) - Ophiobolin A covalently targets complex IV leading to mitochondrial metabolic collapse in cancer cells.Gowans FA, Thach DQ, Wang Y, Altamirano Poblano BE, Dovala D, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK*
ACS Chemical Biology, 2024, 19, 1260-1270. PMID 38739449. (*co-corresponding authorship)
(Novartis-Berkeley Translational Chemical Biology Institute paper) - FATP5 is indispensable for the growth of intrahepatic cholangiocarcinomaShihadih D, Wang X, Zushin P-JH, Khodakivskyi P, Park HM, Tso E, Shiblak J, Misic A, Louie SM, Ward C, Hellerstein M, Nomura DK, Goun E, Urigo F, Calvisi DF, Chen X, Stahl A
Molecular Cancer Research, 2024, 22, 585-595. PMID 38358323 - Exploiting the Cullin E3 ligase adaptor protein SKP1 for targeted protein degradationHong SH*, Divakaran A*, Osa A, Huang OW, Wertz IE, Nomura DK
ACS Chemical Biology, 2024, 19, 442-450. PMID 37904950. (*co-first authors) - Targeted protein degradation through recruitment of the CUL4 complex adaptor protein DDB1Meyers M, Cismoski S, Panidapu A, Chie-Leon B, Nomura DK
ACS Chemical Biology, 2024, 19, 58-68. PMID 38192078
(Novartis-Berkeley Translational Chemical Biology Institute paper)
2023
- A cellular platform for production of C4 monomersDavis MA, Yu VY, Fu B, Wen M, Koleski EJ, Silverman J, Berdan CA, Nomura DK, Chang MCY
Chemical Science, 2023, 14, 11718-11726. PMID 37920356 - Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolismPham VN, Bruemmer KJ, Toh JDW, Ge EJ, Tenney L, Ward CC, Fingler FA, Millington CL, Garcia-Prieto CA, Pulos-Holmes MC, Ingolia NT, Pontel LB, Esteller M, Patel KJ, Nomura DK, Chang CJ
Science, 2023, 382, eabp9201. PMID 37917677 - Mercapto-pyrmidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replicationBajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N
RSC Advances, 2023, 13, 17667-17677. PMID 37312993 - Covalent targeting of glutamate cysteine ligase to inhibit glutathione synthesisZhang L, Tang M, Tao X, Shao Q, Thomas V, Shimizu S, Kasano M, Ishikawa Y, Inukai T, Nomura DK
Chembiochem, 2023, 24, e202300371. PMID 37756477 - N-acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomicsKoo T-Y, Lai H, Nomura DK, Chung CY-K.
Nature Communications, 2023, https://doi.org/10.1038/s41467-023-39268-w. - A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replicationHan H, Gracia AV, Roise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N.
RSC Advances, 2023, 13, 10636-10641. PMID 37025664 - Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell agingBenjamin DI, Brett JO, Both P, Benjamin JS, Ishak HL, Kang J, Kim S, Chung M, Arjona M, Nutter CW, Tan JH, Krishnan AK, Dulay H, Louie SM, de Morree A, Nomura DK, Rando TA
Cell Metabolism, 2023, 35, 472-486. PMID 36854304 - Rational Chemical Design of Molecular Glue DegradersToriki ES*, Papatzimas JW*, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song J-G, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK
ACS Central Science, 2023, 9, 915-926. (* co-first authorship)
(Novartis-Berkeley Translational Chemical Biology Institute paper) - Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-kBKing EA, Cho Y, Hsu, NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Cell Chemical Biology, 2023, 30, 394-402. PMID 36898369
(Novartis-Berkeley Translational Chemical Biology Institute paper) - Targeted Protein Degradation through E2 RecruitmentForte N, Dovala D, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK
ACS Chemical Biology, 2023, https://doi.org/10.1021/acschembio.3c00040. PMID 36940189
(Novartis-Berkeley Translational Chemical Biology Institute paper)
- Discovery of potent pyrazoline-based covalent SARS-CoV-2 main protease inhibitorsMoon P*, Zammt CM*, Shao Q*, Dovala D*, Boike L*, Henning NJ*, Knapp M*, Spradlin JN*, Ward CC*, Wolleb H*, Fuller D, Blake G, Murphy JP, Wang F, Lu Y, Moquin SA, Tandeske L, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Toste FD#, Nomura DK#
Chembiochem, 2023, https://doi.org/10.1002/cbic.202300116. (*co-first authors; #co-corresponding authors)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3Belcher BP, Machicao PA, Tong B, Ho E, Friedli J, So B, Bui H, Isobe Y, Maimone TJ#, Nomura DK#
Chembiochem, 2023, doi: 10.1002/cbic.202300111. PMID 36964942 (#co-corresponding authors). (#co-corresponding authors) - Ligandability of E3 Ligases for Targeted Protein Degradation ApplicationsBelcher B, Ward CC, Nomura DK
Biochemistry, 2023, 62, 588-600. PMID 34473924
2022
- Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim C-Y, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R
Science, 2022, 377, 1290-1298. PMID 36007018 - Advances in covalent drug discoveryBoike L*, Henning NJ*, Nomura DK
Nature Reviews Drug Discovery, 2022, 21, 881-898. PMID 36008483 (*co-first authors) - Tyrosinase-Mediated Synthesis of Nanobody-Cell ConjugatesMaza JC, Garcia-Almedina DM, Boike LE, Hamlish NX, Nomura DK, Francis MB
ACS Central Science, 2022, 8, 955-962. PMID 35912347 - Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signalingBenjamin DI, Both P, Benjamin JS, Nutter CW, Tan JH, Kang J, Machado LA, Klein JDD, de Morree A, Kim S, Liu L, Dulay H, Feraboli L, Louie SM, Nomura DK, Rando TA
Cell Metabolism 2022, 34, 1-17. PMID 35584694 - Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe designPage ACS, Scholz SO, Keenan KN, Spradlin JN, Belcher BP, Brittain SM, Tallarico JA, McKenna JM, Schirle M, Nomura DK*, Toste FD*
2022, Chemical Science 13, 3851-3856. PMID 35432890 (*co-corresponding author)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Deubiquitinase-Targeting Chimeras for Targeted Protein StabilizationHenning NJ*, Boike L*, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse M, Dovala D, McGregor LM, Veldez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Nature Chemical Biology, 2022, 18, 412-421. PMID 35210618 (* co-first authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
- Discovery of a covalent FEM1B recruiter for targeted protein degradation applicationsHenning NJ*, Manford AG*, Spradlin JN, Brittain SM, Zhang E, McKenna JM, Tallarico JA, Schirle M, Rape M#, Nomura DK#
Discovery of a covalent FEM1B recruiter for targeted protein degradation applications.
JACS, 2022, 144, 701-708. PMID 34994556 (*co-first authorship; #co-corresponding authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper)
2021
- Reimagining Druggability using Chemoproteomic PlatformsSpradlin JN, Zhang E, Nomura DK
Accounts of Chemical Research, 2021, 54, 1801-1813. PMID 33733731 - Chemoproteomics-enabled ligand discovery of covalent RNF114-based degraders that mimic natural product functionLuo M*, Spradlin JN*, Boike L, Tong B, Brittain SM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#.
Cell Chemical Biology, 2021, 28, 559-566. PMID 33513350 (*co-first authorship, # co-corresponding authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYCBoike L*, Cioffi AG*, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK.
Cell Chemical Biology, 2021, 28, 4-13. PMID 32966806 (*co-first authorship)
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Chemical investigations into the biosynthesis of the gymnastatin and dankastatin alkaloidsTong B, Belcher BP, Nomura DK, Maimone TJ
Chemical Science, 2021, 12, 8884-8891. PMID 34257889
(Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Advances and opportunities in targeted protein degradationNomura DK, Dey M
Cell Chemical Biology 15, 887-888. PMID 34270936 - De novo design of SARS-CoV-2 Main Protease InhibitorsTrauner D, Fischer C, Nynke V, Peitsinis Z, Ruhmann P, Yang C, Spradlin J, Dovala D, Nomura D, Zhang Y
2021, Synlett, 33, 458-463. PMID 35282568 - CYP27A1 dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolismCho H, Shen Q, Zhang LH, Okumura M, Kawakami A, Ambrose J, Sigoillot F, Miller HR, Gleim S, Cobos-Correa A, Wang Y, Piechon P, Roma G, Eggiman F, Moore C, Aspesi Jr. P, Mapa FA, Burks H, Ross NT, Krastel P, Hild M, Maimone TJ, Fisher DE, Nomura DK, Tallarico JT, Canham SM, Jenkins JL, Forrester WC
Cell Chemical Biology, 2021, 28, 1407-1419. PMID 33794192 - Mitohormesis reprograms macrophage metabolism to enforce toleranceTimblin GA, Tharp KM, Ford B, Winchenster JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, ten Hoeve J, Nomura DK, Stahl A, Saijo K
Nature Metabolism, 2021, 3, 618-635. PMID 34031590 - Oncogene regulated release of extracellular vesiclesKilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohn RA, Avsaroglu B, L’Etoile ND, Perera RM, Nomura DK, Goga A
Developmental Cell, 2021, 56, 1989-2006. PMID 34118203 - Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze Gahmen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. ACS Infectious Diseases, 2021, 7, 2337-2351. PMID 34129317
- Adhesion-mediated mechanosignaling forces mitohormesisTharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saiko K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM.
Cell Metabolism, 2021, 33, 1322-1341. PMID 34019840 - 4beta-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor.Moldavski O, Zushin P-JH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey SF, Nomura DK, Stahl A, Weiss EJ, Zoncu R
Journal of Lipid Research, 2021, 62, 100051. PMID 33631213 - Lipidome-based targeting of STAT3-driven breast cancer cells using poly-L-glutamic acid-coated layer-by-layer nanoparticlesTosic I, Heppler LN, Egusquiaguirre SP, Boehnke N, Correa S, Costa DF, Grossman EA, Pal S, Richardson D, Ivanov AR, Haas-Kogan DA, Nomura DK, Hammond PT, Frank DA.
Molecular Cancer Therapeutics, 2021, 20, 726-738. PMID 33536189
2020
- Bardoxolone Conjugation Enables Targeted Protein Degradation of BRD4Tong B*, Luo M*, Xie Y, Spradlin JN, Tallarico JA, McKenna JM, Schirle M, Maimone TJ#, Nomura DK#
Scientific Reports, 2020, 10, 15543. PMID 32968148 (*co-first authorship; # co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Manumycin polyketides act as molecular glues between UBR7 and P53Isobe Y, Okumura M, White R, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone TJ*, Nomura DK*
Nature Chemical Biology, 2020, 16, 1189-1198. PMID 32572277 (*co-corresponding author) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - A nimbolide-based kinase degrader preferentially degrades oncogenic BCR-ABLTong B*, Spradlin JN*, Novaes LFT, Zhang E, Hu X, Moeller M, Brittain SM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ#, Nomura DK#
ACS Chemical Biology, 2020, 15, 1788-1794. PMID 32568522 (*co-first authorship; # co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communicationSponton CH, Hosonoro T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradham R, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokohama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S
EMBO Reports, 2020, 21, e49828. PMID 32672883 - Unbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in small cell lung cancer stem cellsColes GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Korgan N, Jackson PK, Narla G, Gordan JD, Shokat K, Sage J
Cancer Cell, 2020, doi: 10.1016/j.ccell.2020.05.003. PMID 32531271 - Neuronal modulation of hepatic lipid accumulation induced by binge-like drinkingIbars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vihelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW
American Journal of Physiology: Endocrinology and Metabolism, 2020, 318, E655-E666. PMID 32045262 - A cellular mechanism to detect and alleviate reductive stressManford AG, Rodriguez-Perez F, Shih KY, Shi Z, Berdan CB, Choe M, Titov DV, Nomura DK, Rape M
Cell, 2020, 183, 46-61. PMID 32941802
2019
- Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibitionChung CY-S*, Shin HR*, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R#, Nomura DK#
Nature Chemical Biology, 2019, 15, 776-785. PMID 31285595 (*co-first authorship; #co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Harnessing the anti-cancer natural product nimbolide for targeted protein degradationSpradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ*, Nomura DK*
Nature Chemical Biology, 2019, 15, 747-755. PMID 31209351 (*co-corresponding authors) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applicationsWard CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK
ACS Chemical Biology, 2019, 14, 2430-2440. PMID 31059647 (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cellsBerdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ*, Nomura DK*
Cell Chemical Biology, 2019, 26, 1027-1035. PMID 31080076 (*co-corresponding authorship) (Novartis-Berkeley Center for Proteomics and Chemistry Technologies paper) - A metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity to the statin class of host-targeted therapeuticsAhyong V, Berdan CA, Burke TP, Nomura DK, Welch MD
mSphere, 2019, 4, e00536-19. PMID 31722991 - The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosisBersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA
Nature, 2019, 575, 688–692. PMID 31634900 - ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type CLim C-Y, Davis O, Shin H, Zhang J, Berdan CB, Jiang X, Counihan JL, Ory D, Nomura DK, Zoncu R
Nature Cell Biology, 2019, 21, 1206-1218. PMID: 31548609 - Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolismLee K, Yesilkanal AE, Wynne JP, Frakenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR
Nature, 2019, 568, 254-258. PMID 30842661 - Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancerWatt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomer MK, Parpargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA
Science Translational Medicine, 2019, 11, eaau5758. PMID 3078288 - Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bonesHerber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA
Nature Communications, 2019, 10, 163. PMID 30635563 - Exogenous monounsaturated fatty acids suppress non-apoptotic cell deathMagtanong L, Ko P-J, To M, Cao JY, Tarangelo AN, Ward CC, Cho KY, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ
Cell Chemical Biology, 2019, 26, 420-432. PMID 30686757 - Development of alky glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-to-mesechymal transition in cancer cellsStazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S
European Journal of Medicinal Chemistry, 2019, 163, 722-735. PMID 30576903 - The ER membrane protein complex (EMC) promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasisVolkmar N, Thezenas M-L, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC
Journal of Cell Science, 2019, 132, jcs223453. PMID 30578317
2018
- Virtual Issue on the Work of John CasidaNomura DK
Chemical Research in Toxicology, 2018, 31, 637-638. PMID 30080400 - Cancer metabolism: current understanding and therapiesCounihan JL, Grossman EA, Nomura DK
Chemical Reviews, 2018, 118, 6893-6923. PMID 29939018 - Chemoproteomics-enabled covalent ligand screening reveals ALDH3A1 as a lung cancer targetCounihan JL*, Wiggenhorn A*, Anderson KE, Nomura DK
ACS Chemical Biology, 2018, 13, 1970-1977. PMID 30004670 (*co-first authors) - Target identification of bioactive covalently-acting natural productsNomura DK* and Maimone TJ*
Current Topics in Microbiology and Immunology, 2018, 420, 351-374. PMID 30105423 (*co-corresponding authorship) - Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociceptionLong JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka T, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM
PNAS, 2018, 115, E6937-E6945. PMID 29967167 - Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brainFernandez RF, Kim SQ, Zhao Y, Foguth RM, Weera MM, Counihan JL, Nomura DK, Chester JA, Cannon JR, Ellis JM
Proceedings of the National Academy of Sciences, U.S.A., 2018, 115, 12525-12530. PMID 30327559 - Metabolomic markers of phthalate exposure in plasma and urine of pregnant womenZhou M, Ford B, Lee D, Huen K, Tran Y, Bradman A, Gunier R, Eskenazi B, Nomura DK, Holland NT
Frontiers in Public Health, 2018, 6, 298. PMID 30406068 - Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissuesWallace M, Green CR, Roberts LS, Lee YM, McCarville J, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover J, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM
Nature Chemical Biology, 2018, 14, 1021-1031. PMID 30327559 - The UPR activator ATF6 responds to proteotoxic and lipotoxic stress by distinct mechanismsTam AB, Roberts LS, Chandra V, Rivera IG, Nomura DK, Forbes DJ, Niwa M
Developmental Cell, 2018, 46, 327-343. PMID 30086303 - Regulation of hepatic lipid accumulation and distribution by Agouti-relation protein in male miceMaier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW
Endocrinology, 2018, 159, 2408-2420. PMID 29750244 - Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogs that stimulate mitochondrial respirationLin H, Long JZ, Roche AM, Svensson KJ, Dou F, Chang MR, Srutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM
Journal of Medicinal Chemistry, 2018, 61, 3224-3230. PMID 29533650 - Deletion of adipose triglyceride lipase links triacylglycerol accumulation to a more aggressive phenotype in A549 lung carcinoma cellsTomin T, Fritz K, Gindlhuber J, Waldherr L, Pucher B, Thallinger GG, Nomura DK, Schittmayer M, Birner-Gruenberger R
Journal of Proteome Research, 2018, 17, 1415-1425. PMID 29457907 - Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV lightPrasse C, Ford B, Nomura DK, Sedlak DL
Proceedings of the National Academy of Sciences, USA, 2018, 115, 2311-2316. PMID 29463747 - Novel K-Ras G12C switch-II covalent binders destabilize Ras and accelerate nucleotide exchangeNnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Ballus TE, Nomura DK, Burke JE, Shokat KM, London N
Journal of Chemical Information and Modeling, 2018, 57, 464-471. PMID 29320178 - Paternal chromosome loss and metabolic collapse result in Xenopus hybrid inviabilityGibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R
Nature, 2018, 553, 337-341. PMID: 29320479 - A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomesBersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA
Developmental Cell, 2018, 44, 97-112. PMID 29275994 - Global proteome remodeling during ER stress involves Hac1-driven expression of long undecoded transcript isoformsVan Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA
Developmental Cell, 2018, 46, 219-235. PMID 30016623 - Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolismPatra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Fernandez-del Castillo C, Nomura DK, Haas W, Bardeesy N
Nature Cell Biology, 2018, 20, 811-822. PMID 29941929
2017
- Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural productsGrossman E*, Ward CC*, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK
Cell Chemical Biology, 2017, 24, 1368-1376.e4. PMID 28919038 (*co-first authorship) - Chemoproteomics-enabled covalent ligand screening reveals a thioredoxin-caspase 3 interaction disruptor that impairs breast cancer pathogenicityAnderson KE, To M, Olzmann JA, Nomura DK
ACS Chemical Biology, 2017, 12, 2522-2528. PMID 28892616 - NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspotsWard CC, Kleinman J, Nomura DK
ACS Chemical Biology, 2017, 12, 1478-1483. PMID 28445029 - Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in Reticulon 4 that impairs ER morphology and cancer pathogenicityBateman LA#, Nguyen TB#, Roberts AM#, Miyamoto DK, Ku W-M, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA*, Nomura DK*
Chemical Communications, 2017, 53, 7234-7237. PMID 28352901 (#co-first authors; *co-corresponding author) - Mapping novel metabolic nodes targeted by anti-cancer drugs that impair triple-negative breast cancer pathogenicityRoberts LS, Yan P, Bateman LA, Nomura DK
ACS Chemical Biology, 2017, 12, 1133-1140. PMID 28248089 - ASS1 is an important metabolic regulator of colorectal cancerBateman LA, Ku W-M, Heslin MJ, Contrearas CM, Skibola CF, Nomura DK
ACS Chemical Biology, 2017, 12, 905-911. PMID 28229591 - Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer targetRoberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Akopian D, Heslin MJ, Contreras CM, Rape M, Skibola CF, Nomura DK
ACS Chemical Biology, 2017, 12, 899-904. PMID 28186401 - Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspotsRoberts AM, Ward CC, Nomura DK
Current Opinion in Biotechnology, 2017, 43, 25-33. PMID 27568596 - Mapping proteome-wide reactivity of the widely used herbicide acetochlor in miceCounihan JL, Duckering M, Dalvie E, Ku W-m, Bateman LA, Fisher KJ, Nomura DK
ACS Chemical Biology, 2017, 12, 635-642. PMID 28094496 - Mapping proteome-wide targets of glyphosate in miceFord B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK
Cell Chemical Biology, 2017, 24, 133-140. PMID 28132892 - DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagyNguyen TB, Louie SM, Daniele J, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA
Developmental Cell, 2017, 42, 9-21. PMID 28697336 - The ubiquitin binding protein TAX1BP mediates autophagasome induction and the metabolic transition of activated T cellsWhang MI, Taveras RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A
Immunity, 2017, 46, 405-420. PMID 28314591 - MYC-driven inhibition of the glumate-cysteine ligase promotes glutathione depletion in liver cancerAnderton B, Camarda R, Balkrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A
EMBO Report, 2017, 18, 569-585. PMID 28219903 - Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intoleranceRuby MA, Massart J, Hunerdosse DM, Schonke M, Correia JC, Louie SM, Ruas JL, Naslund E, Nomura DK, Zierath JR
Cell Reports, 2017, 18, 636-646. PMID 28099843 - Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocationTo M, Peterson CWH, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA
Molecular Biology of the Cell, 2017, 28, 270-284. PMID 27881664 - Cellobiose consumption uncouples extracellular glucose sensing and glucose metabolism in Saccharomyces cerevisiaeChomvong K, Benjamin DI, Nomura DK, Cate JH
mBio, 2017, 8, e00855-17. PMID: 28790206 - Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann Pick C1 signaling complexCastellano, B.M., Thelen, A.M., Moldavski O, Feltes M, van der Welle R, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey D, Nomura DK, Ory DS, Zoncu R
Science, 2017, 355, 1306-1311. PMID 28336668 - Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectorsDe Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo Z-Q, Vance RE
Cell Reports, 2017, 21, 2031-2038. PMID 29166595 - Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockadeLue JW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburh KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, Anderson KE, Evans MJ, O’Donnell VB, Nomura DK, Drake JM, Ritz A, Thomas GV
Genes and Development, 2017, 31, 2067-2084. PMID 29138276 - Glucocorticoid-Angiopoietin-like 4-Ceramide Axis induces insulin resistanceChen T-C, Benjamin DI, Kuo T, Lee RA, Li M-L, Mar D, Costello DE, Nomura DK, Wang J-C
Science Signaling, 2017, 10, eaai7905. PMID 28743803
2016
- PM20D1 secretion by thermogenic adipose cells regulates lipidated amino acid uncouplers of mitochondrial respirationLong JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MT, Jedrychowski MP, Paolo J, Griffin PR, Nomura DK*, Spiegelman BM*
Cell, 2016, 166, 424-435. PMID 27374330 (*co-corresponding authorship) - Protein sialylation regulates a gene expression signature that promotes breast cancer cell pathogenicityKohnz RA, Roberts, LS, DeTomaso D, Badyopadhyay S, Yosef N, Nomura DK
ACS Chemical Biology, 2016, 11, 2131-2139. PMID 27380425 - GSTP1 is a driver of triple-negative breast cancer cell metabolism and pathogenicityLouie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK
Cell Chemical Biology, 2016, 23, 1-12. PMID 27185638 - Mapping Proteome-Wide Interactions of Reactive Chemicals using Chemoproteomic PlatformsCounihan JC, Ford B, Nomura DK
Current Opinions in Chemical Biology, 2016, 30, 68-76. PMID 26647369 - Lipases and their inhibitors in health and diseaseNomura DK, Casida JE
Chemico-Biological Interactions, 2016, 259, 211-222. PMID 27067293 - Omics: The maturation of chemical biologySaghatelian A, Nomura DK, Weerapana E
Current Opinions in Chemical Biology, 2016, 30: v-vi. PMID 26739665 - Bypassing the pentose phosphate pathway: Towards modular utilization of xyloseChomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JHD
Plos One, 2016, 11, e0158111. PMID 27336308 - HIF-1alpha is an essential mediator of IFN-gamma-dependent immunity to Mycobacterium tuberculosisBraverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA
Journal of Immunology, 2016, 197, 1287-97. PMID 27430718 - Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancerCamarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A
Nature Medicine, 2016, 22, 427-432. PMID 26950360 - Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosisSogi K, Holsclaw C, Fragiadakis G, Nomura DK, Leary J, Bertozzi C
ACS Infectious Diseases, 2016, 2, 800-806. PMID 27933784 - The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphomaZhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola C
Oncoscience, 2016, 3, 31-41. PMID 26973858 - Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress responseKim H-E, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff Suzanne, Dillin A
Cell, 2016, 166, 1539-1552. PMID 27568596 - Mitochondrial DNA replication defects disturb cellular dNTP pools and remodel one-carbon metabolismNikkanen J, Forsstrom S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamaki J, Roivainen A, Marjamaki P, Liljenback H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lonnqvist T, Sajantila A, Isohanni P, Tyynaismaa H, Nomura DK, Battersby B, Velagapudi V, Carroll CJ, Suomalainen A
Cell Metabolism, 2016, 23, 635-648. PMID 26924217
2015
- Diacylglycerol metabolism and signaling is a predictive and driving force underlying FASN inhibitor sensitivity in cancer cellsBenjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK
ACS Chemical Biology, 2015, 10, 1616-1623. PMID: 25871544 - Mapping Proteome-Wide Targets of Environmental Chemicals using Reactivity-Based Chemoproteomic PlatformsMedina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK
Chemistry & Biology, 2015, 22, 1394-1405. PMID 26496688 - Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agentsPiano V#, Benjamin DI#, Valente S, Nenci S, Mai A, Aliverti A, Nomura DK*, Mattevi A*
ACS Chemical Biology, 2015, 10, 2589-97. PMID 26322624 (# equal contribution; * co-corresponding authors) - Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in CancerKohnz RA, Mulvihill MM, Chang JW, Hsu K-L, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK
ACS Chemical Biology, 2015, 10, 1624-1630 PMID: 25945974 - A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survivalChang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu K-L, Cravatt BF
ACS Chemical Biology, 2015, 10, 925-32. PMID: 25602368 - Ski regulates Hippo and TAZ signaling to suppress breast cancer progressionRashidian J, Le Scolan E, Ji X, Mulvihill MM, Nomura DK, Luo K
Science Signaling, 2015, 10, ra14. PMID: 25670202 - Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptakeAnderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RLS, Quinlan CL, Ng R, Jastroch, M, Benjamin DI, Nie B, Herber C, Van A-AN, Park MK, Yun D, Chan K, Yu A, Vuong P, Febbraio M, Nomura DK, Napoli JL, Brand MD, Stahl A
Cell Reports, 2015, 10, 505-515. PMID: 25620701 - Comparative metabolic profiling of mce1 operon mutant vs wild-type Mycobacterium tuberculosis strainsQueiroz A, Medina-Cleghorn D, Marjanovic O, Nomura DK, Riley LW
Pathogens and Disease, 2015, 73, ftv066. PMID26319139 - Monoacylglycerol lipase regulates fever responseSanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B
PLoS One. 10, e0134437. PMID: 26287872
2014
- Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoidsKohnz RK, Nomura DK
Chemical Society Reviews, 2014, 43, 6859-6869. PMID: 24676249 - Metabolic Profiling Reveals PAFAH1B3 as a critical driver of breast cancer pathogenicityMulvihill MM, Benjamin DI, LeScolan E, Ji X, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK
Chemistry & Biology, 2014, 21, 831-840. PMID: 24954006 - INPP1 Promotes Cancer Aggressiveness by Linking Inositol Phosphate Recycling to Glycolytic and Lipid MetabolismBenjamin DI, Louie S, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandhyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng-SW, Nomura DK
ACS Chemical Biology, 2014, 20, 1340-1350. PMID: 24738946 - Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering TargetHunerdosse D, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh J, Zhong S, Nomura DK
ACS Chemical Biology, 2014, 9, 2905-13. PMID: 25343321 - Metabolomic Strategies to Map Functions of Metabolic PathwaysMulvihill MM, Nomura DK
AJP Metabolism and Endocrinology, 2014, 307, E237-E244. PMID: 24918200 - Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemiaMorris PJ*, Medina-Cleghorn D*, Heslin A, King S, Orr J, Krauss RM, Nomura DK
ACS Chemical Biology, 2014, 9, 1097-1103. (*authors contributed equally to the work) PMID: 24597639 - Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticidesMedina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK
ACS Chemical Biology, 2014, 9, 423-432. PMID: 24205821 - Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platformsMedina-Cleghorn D, Nomura DK
Chemistry & Biology, 2014, 21, 1171-1184. PMID: 25237861 - Activity-based proteomic and metabolomic approaches for understanding metabolismHunerdosse D, Nomura DK
Current Opinion in Biotechnology, 2014, 28C, 116-126. PMID 24594637 - Feeding dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine systemPoole D, Lee M, Tso P, Bunnett N, Yo S, Lieu T, Shiu A, Wang J-C, Nomura DK, and Aponte GW
AJP-Gastrointestinal and Liver Physiology, 2014, 306, G686-G698. PMID: 24578341 - Integrated phenotypic screening and activity-based proteomics defines a role for carboxylesterase 3 in obesity and diabetesDominguez E, Galmozzi A, Chang JW, Hsu K-L, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O’Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E
Nature Chemical Biology, 2014, 10, 113-121. PMID: 24362705 - Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in aged Ts65Dn mice, a model of Down SyndromeLysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RAB, Kleschevnikov AM
Plos One, 2014, 9, e114521. PMID: 25474204 - Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiaeLatimer LN, Lee MR, Medina-Cleghorn D, Kohnz RA, Nomura DK, Dueber JE
Metabolic Engineering, 2014, 25, 20-29. PMID: 24930894 - Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal FunctionValdearcos M, Robblee M, Benjamin DI, Nomura DK, Xu AW, Koliwad SK
Cell Reports, 2014, 9, 1-15. PMID: 25497089
2013
- Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicityBenjamin DI, Cozzo A, Ji X, Roberts LS, Louie SM, Luo K, Nomura DK.
Proceedings of the National Academy of Sciences, USA, 2013, 110, 14912-14917. PMID: 23980144 - Lipid Metabolism in CancerNomura DK, Cravatt BF
Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids, 2013, 1831, 1497-1498. PMID: 23921253 - Cancer cells incorporate and remodel exogenous fatty acids into structural and oncogenic signaling lipidsLouie SM*, Roberts LS*, Mulvihill MM, Luo K, Nomura DK
Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids, 2013, 1831, 1566-1572. PMID: 23872477 (* authors contributed equally to the work) - Mechanisms linking obesity and cancerLouie SM, Roberts LS, Nomura DK
Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids, 2013, 1831, 1499-1508. PMID: 23470257 - Chemical Approaches to Study Metabolic NetworksMedina-Cleghorn D, Nomura DK
Pflugers Archive, 2013, 465,427-440. PMID: 23296751 - Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in miceCao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdelyi K, Hao E, Holovac E, Hasko G, Cravatt BF, Nomura DK#, Pal Pacher#
Gastroenterology, 2013, 144, 808-817. PMID: 23295443 (# co-corresponding authors) - Therapeutic Potential of Monoacylglycerol Lipase InhibitorsMulvihill MM, Nomura DK
Life Sciences, 2013, 92, 492-497. PMID: 23142242
2012
- Global Profiling Strategies towards Mapping Dysregulated Metabolic Pathways in CancerBenjamin DI, Cravatt BF, Nomura DK
Cell Metabolism, 2012, 16, 565-567. PMID: 23063552 - A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer’s DiseasePiro JR, Benjamin DI, Duerr JM, Pi YQ, Gonzales C, Schwartz JW, Nomura DK#, Samad TA#
Cell Reports, 2012, 1, 617-623. PMID: 22813736 (# co-corresponding author) - IL-13Ralpha1 expression in dopaminergic neurons contributes to their oxidative stress-mediates loss following chronic systemic treatment with LPSMorrison BE, Garibaldi Marcondes MC, Nomura DK, Sanchez-Alavez M, Saar I, Bartfai T, Maher P, Sugama S, Conti B
Journal of Immunology, 2012, 189, 5498-5502. PMID: 23169588
2011
- Overactive endocannabinoid signaling induces hepatic steatosis, insulin resistance, and global transcriptional changesRuby MA, Nomura DK, Hudak CSS, Barber A, Casida JE, Krauss RM
Plos One, 2011, 6, e26415. PMID: 22073164 - Endocannabinoid hydrolysis generates brain eicosanoids that promote neuroinflammationNomura DK#, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF#
Science, 2011, 334, 809-813. PMID: 22021672 (# co-corresponding author)
Postdoctoral, Graduate, and Undergraduate Work
2011
- Monoacylglycerol lipase exerts bidirectional control over endocannabinoid and fatty acid pathways to support prostate cancer pathogenesisNomura DK#, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF#
Chemistry & Biology, 2011, 18, 848-856. PMID: 21802006 (# co-corresponding author) - Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple secondary targets in the mammalian nervous systemNomura DK#, Casida JE#
Journal of Agricultural and Food Chemistry, 2011, 59, 2808-2815. PMID: 21341672 (# co-corresponding author) - A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesisChang JW, Nomura DK, Cravatt BF
Chemistry & Biology, 2011, 18, 476-484. PMID: 21513884 - Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory painAhn K, Smith SE, Liimata MB, Sadagopan N, Dudley D, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stif C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF
Journal of Pharmacology and Experimental Therapeutics, 2011, 338, 114-124. PMID: 21505060 - Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitorsBachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schűrer, Nomura DK, Rosen H, Fu GC, Cravatt BF
Proceedings of the National Academy of Sciences, USA, 2011, 108, 6811-6816. PMID: 21398589 - Design, synthesis and biological evaluation of a biyouyanagin compound libraryNicolaou KC, Sanchini S, Sarlah D, Lu G, Wu R, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR
Proceedings of the National Academy of Sciences, USA, 2011, 108, 6715-6720. PMID: 21245351 - Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated withdrawal symptoms in miceRamesh D, Ross GR, Schlosburg JE, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF
Journal of Pharmacology and Experimental Therapeutics, 2011, 339, 173-185. PMID: 21719468 - Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in miceKinsey SG, Nomura DK, O’Neal ST, Long JZ, Cravatt BF, Lichtman AH
Journal of Pharmacology and Experimental Therapeutics, 2011, 338, 795-802. PMID: 21659471
2010
- Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesisNomura DK, Long JZ, Niessen S, Hoover HS, Ng S-W, Cravatt BF
Cell, 2010, 140, 49-61. PMID: 20079333 - Chemoproteomic Approaches for Biochemical Pathway Discovery in CancerNomura DK, Dix MM, Cravatt BF
Nature Reviews Cancer, 2010, 10, 630-638. PMID: 20703252 - Sustained inactivation of monoacylglycerol lipase produces functional antagonism of the brain endocannabinoid systemSchlosburg JE, Blankman JL, Long JZ, Nomura DK, Nguyen PT, Ramesh D, Kinsey SG, Booker L, Burston JK, Wise LE, Ghosh S, Selley DE, Sim-Selley LJ, Liu Q, Cravatt BF, Lichtman AH
Nature Neuroscience, 2010, 13, 1113-1119. PMID: 20729846 - The glycerophospho-metabolome and its influence on amino acid homeostasis by brain metabolomics of GDE1(-/-) miceKopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Simon GM, Cravatt BF
Chemistry & Biology, 2010, 17, 831-840. PMID: 20797612
2009
- Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivoLong JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF
Proceedings of the National Academy of Sciences, USA, 2009, 106, 20270-20275. PMID: 19918051 - Mechanistic characterization of selective monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolismLong JZ, Nomura DK, Cravatt BF
Chemistry & Biology, 2009, 16, 744-753. PMID: 19635411
2008
- Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levelsNomura DK, Ward AM, Hudak CS, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman A, Casida JE
Bioorganic Medicinal Chemistry Letters, 2008, 18, 5875-5878. PMID: 18752948 - Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and EndocannabinoidsCasida JE, Nomura DK, Vose SC, Fujioka K.
Chemico-Biological Interactions, 2008, 175, 355-64. PMID: 18495101 - Activation of the endocannabinoid system by organophosphorus nerve agentsNomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE
Nature Chemical Biology, 2008, 4, 373-378. PMID: 18438404 - Dual Roles of Brain Serine Hydrolase KIAA1363 in Ether Lipid Metabolism and Organophosphate DetoxificationNomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE
Toxicology and Applied Pharmacology, 2008, 228, 42-482. PMID: 18154358 - Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteinsRuby M*, Nomura DK*, Hudak CS, Mangravite LM, Chiu S, Casida JE, Krauss RM
Proceedings of the National Academy of Sciences, USA, 2008, 105, 14561-14566. PMID: 18794527
2006
- Serine Hydrolase KIAA1363: Toxicological and Structural Features with Emphasis on Organophosphate InteractionsNomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE
Chemical Research in Toxicology 19, 1142-1150. PMID: 16978018 - Each Lipase has a Unique Sensitivity Profile for Organophosphorus InhibitorsQuistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE
Toxicological Sciences, 2006, 91,166-172. PMID: 16449251
2005
2003
- Toxicological and Structural Features of Organophosphorus and Organosulfur Cannabinoid CB1 Receptor LigandsSegall Y, Quistad GB, Sparks SE, Nomura DK, Casida JE
Toxicological Sciences, 2003, 76, 131-137. PMID: 12944568 cdesz - Arachidonylsulfonyl Derivatives as Cannabinoid CB1 Receptor and Fatty Acid Amide Hydrolase InhibitorsSegall Y, Quistad GB, Nomura DK, Casida JE
Bioorganic Medicinal Chemistry Letters, 2003, 13,3301-3303. PMID: 12951114
2002
- Cannabinoid CB1 Receptor as a Target for Chlorpyrifos Oxon and Organophosphorus PesticidesQuistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE
Toxicology Letters, 2002, 135, 89-93. PMID: 12243867 - Selective Inhibitors of Fatty Acid Amide Hydrolase Relative to Neuropathy Target Esterase and Acetylcholinesterase: Toxicological ImplicationsQuistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE
Toxicology and Applied Pharmacology, 2002, 179, 57-63. PMID: 11884237
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