Our Publications

Publications

2017

92. Grossman E*, Ward CC*, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK. (2017) Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products. Under review. (*co-first authorship)

91. Chen T-C, Benjamin DI, Kuo T, Lee RA, Li M-L, Mar D, Costello DE, Nomura DK, Wang J-C. (2017) Glucocorticoid-Angiopoietin-like 4-Ceramide Axis induces insulin resistance. Science Signaling doi:10/1126/scisignal.aai7905. PDF

90. Chomvong K, Benjamin DI, Nomura DK, Cate JH. (2017) Cellobiose consumption uncouples extracellular glucose sensing and glucose metabolism in Saccharomyces cerevisiae. In press at mBio.

89. Nguyen TB, Louie SM, Daniele J, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. (2017) DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy. Developmental Cell 42, 9-21. PDF

88. Ward CC, Kleinman J, Nomura DK. (2017) NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspots. ACS Chemical Biology 12, 1478-1483. PMID 28445029 PDF

87. Bateman LA#, Nguyen TB#, Roberts AM#, Miyamoto DK, Ku W-M, Huffman TR, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA*, Nomura DK*. (2017) Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in Reticulon 4 that impairs ER morphology and cancer pathogenicity. Chemical Communications 53, 7234-7237. PMID 28352901 (#co-first authors; *co-corresponding author) PDF

86. Castellano, B.M., Thelen, A.M., Moldavski O, Feltes M, van der Welle R, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey D, Nomura DK, Ory DS, Zoncu R. (2017) Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann Pick C1 signaling complex. Science 355, 1306-1311. PMID 28336668 PDF

85. Roberts LS, Yan P, Bateman LA, Nomura DK. (2017) Mapping novel metabolic nodes targeted by anti-cancer drugs that impair triple-negative breast cancer pathogenicity. ACS Chemical Biology 12, 1133-1140. PMID 28248089 PDF

84. Bateman LA, Ku W-M, Heslin MJ, Contrearas CM, Skibola CF, Nomura DK. (2017) ASS1 is an important metabolic regulator of colorectal cancer. ACS Chemical Biology 12, 905-911. PMID 28229591 PDF

83. Roberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Akopian D, Heslin MJ, Contreras CM, Rape M, Skibola CF, Nomura DK. (2017) Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target. ACS Chemical Biology 12, 899-904. PMID 28186401 PDF

82. Counihan JL, Duckering M, Dalvie E, Ku W-m, Bateman LA, Fisher KJ, Nomura DK. (2017) Mapping proteome-wide reactivity of the widely used herbicide acetochlor in mice. ACS Chemical Biology 12, 635-642. PMID 28094496 PDF

81. Whang MI, Taveras RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. (2017) The ubiquitin binding protein TAX1BP mediates autophagasome induction and the metabolic transition of activated T cells. Immunity 46, 405-420. PMID 28314591 PDF

80. Anderton B, Camarda R, Balkrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A. (2017) MYC-driven inhibition of the glumate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Report 18, 569-585. PMID 28219903 PDF

79. Ford B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK. (2017) Mapping proteome-wide targets of glyphosate in mice. Cell Chemical Biology 24, 133-140. PMID 28132892 PDF

78. Ruby MA, Massart J, Hunerdosse DM, Schonke M, Correia JC, Louie SM, Ruas JL, Naslund E, Nomura DK, Zierath JR. (2017) Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance. Cell Reports 18, 636-646. PMID 28099843 PDF

77. To M, Peterson CWH, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA. (2017) Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation. Molecular Biology of the Cell 28, 270-284. PMID 27881664 PDF

76. Roberts AM, Ward CC, Nomura DK. (2017) Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots. Current Opinion in Biotechnology 43, 25-33. PMID 27568596 PDF

2016

75. Kim H-E, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff Suzanne, Dillin A (2016) Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response. Cell 166, 1539-1552. PMID 27568596 PDF

74. Sogi K, Holsclaw C, Fragiadakis G, Nomura DK, Leary J, Bertozzi C. (2016) Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis. ACS Infectious Diseases 2, 800-806. PMID 27933784 PDF

73. Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA. (2016) HIF-1alpha is an essential mediator of IFA-gamma-dependent immunity to Mycobacterium tuberculosis. Journal of Immunology doi: 10.4049/jimmunol.1600266. PMID 27430718 PDF

72. Kohnz RA, Roberts, LS, DeTomaso D, Badyopadhyay S, Yosef N, Nomura DK. (2016) Protein sialylation regulates a gene expression signature that promotes breast cancer cell pathogenicity. ACS Chemical Biology 11, 2131-2139. PMID 27380425 PDF

71. Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MT, Jedrychowski MP, Paolo J, Griffin PR, Nomura DK*, Spiegelman BM* (2016) PM20D1 secretion by thermogenic adipose cells regulates lipidated amino acid uncouplers of mitochondrial respiration. Cell 166, 424-435. PMID 27374330 (*co-corresponding authorship) PDF

70. Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JHD. (2016) Bypassing the pentose phosphate pathway: Towards modular utilization of xylose. Plos One 11, e0158111. PMID 27336308 PDF

69. Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK. (2016) GSTP1 is a driver of triple-negative breast cancer cell metabolism and pathogenicity. Cell Chemical Biology 23, 1-12. PMID 27185638 PDF

68. Nomura DK, Casida JE (2016) Lipases and their inhibitors in health and disease. Chemico-Biological Interactions doi: 10.1016/j.cbi.2016.04.004. PMID 27067293 PDF

67. Zhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola C (2016) The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma. Oncoscience 3, 31-41. PMID 26973858 PDF

66. Nikkanen J, Forsstrom S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamaki J, Roivainen A, Marjamaki P, Liljenback H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lonnqvist T, Sajantila A, Isohanni P, Tyynaismaa H, Nomura DK, Battersby B, Velagapudi V, Carroll CJ, Suomalainen A (2016) Mitochondrial DNA replication defects disturb cellular dNTP pools and remodel one-carbon metabolism. Cell Metabolism 23, 635-648. PMID 26924217 PDF

65. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. (2016) Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nature Medicine 22, 427-432. PMID 26950360. PDF

64. Saghatelian A, Nomura DK, Weerapana E (2016) Omics: The maturation of chemical biology. Current Opinions in Chemical Biology 30: v-vi. PMID 26739665 PDF

63. Counihan JC, Ford B, Nomura DK. (2016) Mapping Proteome-Wide Interactions of Reactive Chemicals using Chemoproteomic Platforms. Current Opinions in Chemical Biology 30, 68-76. PMID 26647369 PDF

2015

62. Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK. (2015) Mapping Proteome-Wide Targets of Environmental Chemicals using Reactivity-Based Chemoproteomic Platforms. Chemistry & Biology 22, 1394-1405. PMID 26496688 PDF

61. Piano V#, Benjamin DI#, Valente S, Nenci S, Mai A, Aliverti A, Nomura DK*, Mattevi A*. (2015) Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents. ACS Chemical Biology doi: 10.1021/acschembio.5b00466. PMID 26322624 (# equal contribution; * co-corresponding authors). PDF

60. Queiroz A, Medina-Cleghorn D, Marjanovic O, Nomura DK, Riley LW. (2015) Comparative metabolic profiling of Mycobacterium tuberculosis: cell wall lipid reorganization as a virulence factor. Pathogens and Disease pii: ftv066. PMID26319139. PDF

59. Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B. (2015) Monoacylglycerol lipase regulates fever response. PLoS One. 10, e0134437. PMID: 26287872 PDF

58. Kohnz RA, Mulvihill MM, Chang JW, Hsu K-L, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK. (2015) Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. ACS Chemical Biology 10, 1624-1630 PMID: 25945974 PDF

57. Benjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK. (2015) Diacylglycerol metabolism and signaling is a predictive and driving force underlying FASN inhibitor sensitivity in cancer cells. ACS Chemical Biology 10, 1616-1623. PMID: 25871544 PDF

56. Rashidian J, Le Scolan E, Ji X, Mulvihill MM, Nomura DK, Luo K. (2015) Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Science Signaling 10, ra14. PMID: 25670202 PDF

55. Anderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RLS, Quinlan CL, Ng R, Jastroch, M, Benjamin DI, Nie B, Herber C, Van A-AN, Park MK, Yun D, Chan K, Yu A, Vuong P, Febbraio M, Nomura DK, Napoli JL, Brand MD, Stahl A. (2015) Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake. Cell Reports 10, 505-515. PMID: 25620701 PDF

54. Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu K-L, Cravatt BF. (2015) A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chemical Biology 10, 925-32. PMID: 25602368 PDF

2014

53. Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RAB, Kleschevnikov AM. (2014) Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in aged Ts65Dn mice, a model of Down Syndrome. Plos One 9, e114521. PMID: 25474204 PDF

52. Valdearcos M, Robblee M, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. (2014) Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function. Cell Reports 9, 1-15. PMID: 25497089 PDF

51. Hunerdosse D, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh J, Zhong S, Nomura DK. (2014) Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target. ACS Chemical Biology. Doi: 10.1021/cb500717g. PMID: 25343321. PDF

50. Medina-Cleghorn D, Nomura DK. (2014) Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms. Chemistry & Biology 21, 1171-1184. PMID: 25237861. PDF

49. Cai X, Perttula K, Pajouh SK, Hubbard A, Nomura DK, Rappaport SM. (2014) Untargeted lipidomic profiling of human plasma reveals differences due to race, gender, and smoking status. Metabolomics: Open Access 4, 1000131. PDF

48. Mulvihill MM, Nomura DK. (2014) Metabolomic Strategies to Map Functions of Metabolic Pathways. AJP Metabolism and Endocrinology 307, E237-E244. PMID: 24918200 PDF

47. Latimer LN, Lee MR, Medina-Cleghorn D, Kohnz RA, Nomura DK, Dueber JE. (2014) Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae. Metabolic Engineering 25, 20-29. PMID: 24930894. PDF

46. Mulvihill MM, Benjamin DI, LeScolan E, Ji X, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK. (2014) Metabolic Profiling Reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Chemistry & Biology 21, 831-840. PMID: 24954006 PDF

45. Benjamin DI, Louie S, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandhyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng-SW, Nomura DK. (2014) INPP1 Promotes Cancer Aggressiveness by Linking Inositol Phosphate Recycling to Glycolytic and Lipid Metabolism. ACS Chemical Biology 20, 1340-1350. PMID: 24738946 PDF

44. Kohnz RK, Nomura DK. (2014) Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. Chemical Society Reviews 43, 6859-6869. PMID: 24676249 PDF

43. Morris PJ*, Medina-Cleghorn D*, Heslin A, King S, Orr J, Krauss RM, Nomura DK. (2014) Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. ACS Chemical Biology 9, 1097-1103. (*authors contributed equally to the work) PMID: 24597639 PDF

42. Hunerdosse D, Nomura DK. (2014) Activity-based proteomic and metabolomic approaches for understanding metabolism. Current Opinion in Biotechnology 28C, 116-126. PMID 24594637 PDF

41. Poole D, Lee M, Tso P, Bunnett N, Yo S, Lieu T, Shiu A, Wang J-C, Nomura DK, and Aponte GW. (2014) Feeding dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system. AJP-Gastrointestinal and Liver Physiology 306, G686-G698. PMID: 24578341 PDF

40. Dominguez E, Galmozzi A, Chang JW, Hsu K-L, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O’Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. (2014) Integrated phenotypic screening and activity-based proteomics defines a role for carboxylesterase 3 in obesity and diabetes. Nature Chemical Biology 10, 113-121. PMID: 24362705 PDF

39. Medina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK. (2014) Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides. ACS Chemical Biology 9, 423-432. PMID: 24205821 PDF

2013

38. Nomura DK, Cravatt BF. (2013) Lipid Metabolism in Cancer. Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids 1831, 1497-1498. PMID: 23921253 PDF

37. Benjamin DI, Cozzo A, Ji X, Roberts LS, Louie SM, Luo K, Nomura DK. (2013) The ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids that fuel cancer pathogenicity. Proceedings of the National Academy of Sciences, USA 110, 14912-14917. PMID: 23980144 PDF

36. Louie SM*, Roberts LS*, Mulvihill MM, Luo K, Nomura DK. (2013) Cancer cells incorporate and remodel exogenous fatty acids into structural and oncogenic signaling lipids. Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids 1831, 1566-1572. PMID: 23872477 (* authors contributed equally to the work) PDF

35. Louie SM, Roberts LS, Nomura DK. (2013) Mechanisms linking obesity and cancer. Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids 1831, 1499-1508. PMID: 23470257 PDF

34. Medina-Cleghorn D, Nomura DK. (2013) Chemical Approaches to Study Metabolic Networks. Pflugers Archive 465,427-440. PMID: 23296751 PDF

33. Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdelyi K, Hao E, Holovac E, Hasko G, Cravatt BF, Nomura DK#, Pal Pacher#. (2013) Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology 144, 808-817. PMID: 23295443 (# co-corresponding authors) PDF

32. Mulvihill MM, Nomura DK. (2013) Therapeutic Potential of Monoacylglycerol Lipase Inhibitors. Life Sciences 92, 492-497. PMID: 23142242 PDF

2012

31. Morrison BE, Garibaldi Marcondes MC, Nomura DK, Sanchez-Alavez M, Saar I, Bartfai T, Maher P, Sugama S, Conti B. (2012) IL-13Ralpha1 expression in dopaminergic neurons contributes to their oxidative stress-mediates loss following chronic systemic treatment with LPS. Journal of Immunology 189, 5498-5502. PMID: 23169588 PDF

30. Benjamin DI, Cravatt BF, Nomura DK. (2012) Global Profiling Strategies towards Mapping Dysregulated Metabolic Pathways in Cancer. Cell Metabolism 16, 565-567. PMID: 23063552 PDF

29. Piro JR, Benjamin DI, Duerr JM, Pi YQ, Gonzales C, Schwartz JW, Nomura DK#, Samad TA#. (2012) A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer’s Disease. Cell Reports 1, 617-623. PMID: 22813736 (# co-corresponding author) PDF

2011

28. Nomura DK#, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF#. (2011) Endocannabinoid hydrolysis generates brain eicosanoids that promote neuroinflammation. Science 334, 809-813. PMID: 22021672 (# co-corresponding author) PDF

27. Ruby MA, Nomura DK, Hudak CSS, Barber A, Casida JE, Krauss RM. (2011) Overactive endocannabinoid signaling induces hepatic steatosis, insulin resistance, and global transcriptional changes. Plos One 6, e26415. PMID: 22073164 PDF

Undergraduate, Graduate, Postdoctoral Work (2002-2011)

2011

26. Nomura DK#, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF#. (2011) Monoacylglycerol lipase exerts bidirectional control over endocannabinoid and fatty acid pathways to support prostate cancer pathogenesis. Chemistry & Biology 18, 848-856. PMID: 21802006 (# co-corresponding author) PDF

25. Ramesh D, Ross GR, Schlosburg JE, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF. (2011) Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated withdrawal symptoms in mice. Journal of Pharmacology and Experimental Therapeutics 339, 173-185. PMID: 21719468 PDF

24. Kinsey SG, Nomura DK, O’Neal ST, Long JZ, Cravatt BF, Lichtman AH. (2011) Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice. Journal of Pharmacology and Experimental Therapeutics 338, 795-802. PMID: 21659471 PDF

23. Chang JW, Nomura DK, Cravatt BF. (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chemistry & Biology 18, 476-484. PMID: 21513884 PDF

22. Ahn K, Smith SE, Liimata MB, Sadagopan N, Dudley D, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stif C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF. (2011) Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain. Journal of Pharmacology and Experimental Therapeutics 338, 114-124. PMID: 21505060 PDF

21. Nomura DK#, Casida JE#. (2011) Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple secondary targets in the mammalian nervous system. Journal of Agricultural and Food Chemistry 59, 2808-2815. PMID: 21341672 (# co-corresponding author) PDF

20. Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu R, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR. (2011) Design, synthesis and biological evaluation of a biyouyanagin compound library. Proceedings of the National Academy of Sciences, USA 108, 6715-6720. PMID: 21245351 PDF

19. Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schűrer, Nomura DK, Rosen H, Fu GC, Cravatt BF. (2011) Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences, USA 108, 6811-6816. PMID: 21398589 PDF

2010

18. Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Simon GM, Cravatt BF. (2010) The glycerophospho-metabolome and its influence on amino acid homeostasis by brain metabolomics of GDE1(-/-) mice. Chemistry & Biology 17, 831-840. PMID: 20797612 PDF

17. Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Nguyen PT, Ramesh D, Kinsey SG, Booker L, Burston JK, Wise LE, Ghosh S, Selley DE, Sim-Selley LJ, Liu Q, Cravatt BF, Lichtman AH. (2010) Sustained inactivation of monoacylglycerol lipase produces functional antagonism of the brain endocannabinoid system. Nature Neuroscience 13, 1113-1119. PMID: 20729846 PDF

16. Nomura DK, Dix MM, Cravatt BF. (2010) Chemoproteomic Approaches for Biochemical Pathway Discovery in Cancer. Nature Reviews Cancer 10, 630-638. PMID: 20703252 PDF

15. Nomura DK, Long JZ, Niessen S, Hoover HS, Ng S-W, Cravatt BF. (2010) Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140, 49-61. PMID: 20079333 PDF

2009

14. Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF. (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences, USA 106, 20270-20275. PMID: 19918051 PDF

13. Long JZ, Nomura DK, Cravatt BF. (2009) Mechanistic characterization of selective monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chemistry & Biology 16, 744-753. PMID: 19635411 PDF

2008

12. Ruby M*, Nomura DK*, Hudak CS, Mangravite LM, Chiu S, Casida JE, Krauss RM. (2008) Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proceedings of the National Academy of Sciences, USA 105, 14561-14566. PMID: 18794527 (* co-first author) PDF

11. Nomura DK, Ward AM, Hudak CS, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman A, Casida JE. (2008) Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorganic Medicinal Chemistry Letters 18, 5875-5878. PMID: 18752948 PDF

10. Casida JE, Nomura DK, Vose SC, Fujioka K. (2008) Organophosphate-Sensitive Lipases Modulate Brain Lysophospholipids, Ether Lipids and Endocannabinoids. Chemico-Biological Interactions 175, 355-64. PMID: 18495101 PDF

9. Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008) Activation of the endocannabinoid system by organophosphorus nerve agents. Nature Chemical Biology 4, 373-378. PMID: 18438404 PDF

8. Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008) Dual Roles of Brain Serine Hydrolase KIAA1363 in Ether Lipid Metabolism and Organophosphate Detoxification. Toxicology and Applied Pharmacology 228, 42-482. PMID: 18154358 PDF

2006

7. Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2006) Serine Hydrolase KIAA1363: Toxicological and Structural Features with Emphasis on Organophosphate Interactions. Chemical Research in Toxicology 19, 1142-1150. PMID: 16978018 PDF

6. Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE. (2006) Each Lipase has a Unique Sensitivity Profile for Organophosphorus Inhibitors. Toxicological Sciences 91,166-172. PMID: 16449251 PDF

2005

5. Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2005) A Brain Detoxifying Enzyme for Organophosphorus Nerve Poisons. Proceedings of the National Academy of Sciences, USA 102, 6195-6200. PMID: 15840715 PDF

2003

4. Segall Y, Quistad GB, Sparks SE, Nomura DK, Casida JE. (2003) Toxicological and Structural Features of Organophosphorus and Organosulfur Cannabinoid CB1 Receptor Ligands. Toxicological Sciences 76, 131-137. PMID: 12944568 PDF

3. Segall Y, Quistad GB, Nomura DK, Casida JE. (2003) Arachidonylsulfonyl Derivatives as Cannabinoid CB1 Receptor and Fatty Acid Amide Hydrolase Inhibitors. Bioorganic Medicinal Chemistry Letters 13,3301-3303. PMID: 12951114 PDF

2002

2. Quistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE. (2002) Cannabinoid CB1 Receptor as a Target for Chlorpyrifos Oxon and Organophosphorus Pesticides. Toxicology Letters 135, 89-93. PMID: 12243867 PDF

1. Quistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE. (2002) Selective Inhibitors of Fatty Acid Amide Hydrolase Relative to Neuropathy Target Esterase and Acetylcholinesterase: Toxicological Implications. Toxicology and Applied Pharmacology 179, 57-63. PMID: 11884237 PDF

Patents

Cravatt BF, Nomura DK, Chang JW, Moellering M, Bachovchin, D, Li, W. (2011) Anti-cancer serine hydrolase inhibitory carbamates. PCT/US2011/057321 PDF

Cravatt BF, Long JZ, Li W, Nomura DK. (2010) Methods and Compositions Related to Targeting Monoacylglycerol Lipase. US Patent 8772318; PCT/US2009/006045. PDF